Publication Name	World Journal of Virology
Manuscript ID	31125
Country	Spain

Received	2016-10-31 11:10
Peer-Review Started	2016-11-03 17:20
First Decision by Editorial Office Director
Return for Revision	2016-12-07 08:31
Revised	2016-12-20 16:14
Publication Fee Transferred
Second Decision by Editor	2017-01-18 11:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-02-13 13:54
Articles in Press	2017-02-13 13:54
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-06 20:00
Publish the Manuscript Online	2017-05-12 22:16

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Allergy
Manuscript Type	Observational Study
Article Title	Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients
Manuscript Source	Invited Manuscript
All Author List	Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón and Víctor Asensi
Funding Agency and Grant Number	Funding Agency Grant Number the Oviedo University research grants UNIOV-12-MA-03 the Oviedo University research grants SV-PA-13-ECOEMP-57
Corresponding Author	Dr. Julio Collazos, Infectious Diseases Unit, Hospital de Galdácano, Bº Labeaga s/n, 48960 Vizcaya, Spain. med003033@gmail.com
Key Words	Human immunodeficiency virus; Hepatitis C virus; Liver fibrosis; Transient elastometry; Non-invasive fibrosis markers; Metalloproteases; Their tissue inhibitors; Genetic polymorphisms
Core Tip	The role of matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) in the development of liver fibrosis is uncertain. We determined some single nucleotide polymorphisms (SNPs), as well as the serum levels of diverse MMPs and TIMPs, in non-alcoholic, human immunodeficiency virus-infected patients with/out hepatitis C virus coinfection, to evaluate their possible relationship with liver fibrosis as assessed by transient elastometry. MMP-2 was independently associated with significant fibrosis. Likewise, MMP-2, TIMP-2 and MMP-9 were independent predictors of transient elastometry values and of other non-invasive tests of fibrosis. No SNP was significantly associated with liver fibrosis. Our findings support the value of these markers in the evaluation of fibrosis.
Publish Date	2017-05-12 22:16
Citation	Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol 2017; 6(2): 36-45
URL	http://www.wjgnet.com/2220-3249/full/v6/i2/36.htm
DOI	http://dx.doi.org/10.5501/wjv.v6.i2.36

Full Article (PDF)	WJV-6-36.pdf
Full Article (Word)	WJV-6-36.doc