Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	31221
Country	Spain

Received	2016-11-05 12:09
Peer-Review Started	2016-11-05 15:42
To Make the First Decision	2016-12-13 15:50
Return for Revision	2016-12-14 10:37
Revised	2017-01-14 03:48
Second Decision	2017-01-18 11:16
Accepted by Journal Editor-in-Chief	2017-01-18 22:20
Accepted by Executive Editor-in-Chief	2017-02-13 13:55
Articles in Press	2017-02-13 13:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-28 10:05
Publish the Manuscript Online	2017-05-04 08:16

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting
Manuscript Source	Invited Manuscript
All Author List	Huascar Ramos, Pedro Linares, Ester Badia, Isabel Martín, Judith Gómez, Carolina Almohalla, Francisco Jorquera, Sara Calvo, Isidro García, Pilar Conde, Begoña Álvarez, Guillermo Karpman, Sara Lorenzo, Visitación Gozalo, Mónica Vásquez, Diana Joao, Marina de Benito, Lourdes Ruiz, Felipe Jiménez, Federico Sáez-Royuela and Asociación Castellano y Leonesa de Hepatología (ACyLHE).
Funding Agency and Grant Number	Funding Agency Grant Number Fundación Burgos por la Investigación de la Salud and Gerencia Regional de Salud de Castilla y León BUO/06/15
Corresponding Author	Federico Sáez-Royuela, MD, PhD, Department of Gastroenterology and Hepatology, Hospital Universitario de Burgos, Avda, Islas Baleares 3, 09006 Burgos, Spain. fsroyuela@gmail.com
Key Words	Hepatitis C virus infection; Genotype 1-4; Real world treatment; Direct-acting antiviral agents
Core Tip	Our study analyzes the hepatitis C virus (HCV) most common genotypes treatment and all the possible combinations with direct-acting antiviral agents which are nowadays available in our country. We have found sustained virological response rates up to 90%, even in genotypes 1 and 3. The current study analyzes HCV RNA after 4 wk of treatment and 12 and 24 wk after the end of the treatment, as well as the adverse events. We analyze, separately, the patients who meet or do not meet the inclusion criteria of a clinical trial, finding that in this last group the response is lower.
Publish Date	2017-05-04 08:16
Citation	Ramos H, Linares P, Badia E, Martín I, Gómez J, Almohalla C, Jorquera F, Calvo S, García I, Conde P, Álvarez B, Karpman G, Lorenzo S, Gozalo V, Vásquez M, Joao D, de Benito M, Ruiz L, Jiménez F, Sáez-Royuela F; Asociación Castellano y Leonesa de Hepatología (ACyLHE). Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting. World J Gastrointest Pharmacol Ther 2017; 8(2): 137-146
URL	http://www.wjgnet.com/2150-5349/full/v8/i2/137.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v8.i2.137

Full Article (PDF)	WJGPT-8-137.pdf
Full Article (Word)	WJGPT-8-137.doc
Manuscript File	31221-Review.docx
Answering Reviewers	31221-Answering reviewers.pdf
Audio Core Tip	31221-Audio core tip.aif
Biostatistics Review Certificate	31221-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31221-Conflict-of-interest statement.pdf
Copyright License Agreement	31221-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31221-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161104201740.pdf
Institutional Review Board Approval Form or Document	31221-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31221-Language certificate.pdf
Supplementary Material	31221-Supplementary material.pdf
Peer-review Report	31221-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31221-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31221-Scientific misconduct check.pdf
Scientific Editor Work List	31221-Scientific editor work list.pdf