Publication Name	World Journal of Cardiology
Manuscript ID	31249
Country	Japan

Received	2016-11-10 09:26
Peer-Review Started	2016-11-10 15:46
First Decision by Editorial Office Director
Return for Revision	2016-11-30 15:09
Revised	2016-12-21 20:27
Publication Fee Transferred
Second Decision by Editor	2017-01-04 16:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-01-14 14:11
Articles in Press	2017-01-14 14:11
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-20 13:26
Publish the Manuscript Online	2017-02-23 11:56

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Association between high cystatin C levels and carotid atherosclerosis
Manuscript Source	Unsolicited Manuscript
All Author List	Toshiyuki Kobayashi, Hirohide Yokokawa, Kazutoshi Fujibayashi, Tomomi Haniu, Teruhiko Hisaoka, Hiroshi Fukuda and Toshio Naito
Funding Agency and Grant Number
Corresponding Author	Toshiyuki Kobayashi, MD, Department of General Medicine, Zama General Hospital, 1-50-1, Sobudai, Zama City, Kanagawa 252-0011, Japan. tykobaya@juntendo.ac.jp
Key Words	Cystatin C; Atherosclerosis; Carotid plaque; Maximum carotid plaque thickness; Visceral fat
Core Tip	Atherosclerosis is a leading worldwide cause of morbidity and mortality. The association between cystatin C (CysC) and atherosclerotic disorders remains controversial, and the cut-off value of CysC for atherosclerosis is unknown. Our study revealed that the optimal CysC cut-off point was 0.73 mg/L by receiver operating characteristic curve analysis. Higher CysC levels were significantly and independently correlated with an maximum carotid plaque thickness of ≥ 2 mm in multivariate analysis. Our data indicate that CysC could be a useful laboratory tool for predicting atherosclerosis during health checkups.
Publish Date	2017-02-23 11:56
Citation	Kobayashi T, Yokokawa H, Fujibayashi K, Haniu T, Hisaoka T, Fukuda H, Naito T. Association between high cystatin C levels and carotid atherosclerosis. World J Cardiol 2017; 9(2): 174-181
URL	http://www.wjgnet.com/1949-8462/full/v9/i2/174.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i2.174

Full Article (PDF)	WJC-9-174.pdf
Full Article (Word)	WJC-9-174.doc
Manuscript File	31249-Review.docx
Answering Reviewers	31249-Answering reviewers.pdf
Audio Core Tip	31249-Audio core tip.mp3
Biostatistics Review Certificate	31249-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31249-Conflict-of-interest statement.pdf
Copyright License Agreement	31249-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161106085734.pdf
Institutional Review Board Approval Form or Document	31249-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31249-Language certificate.pdf
Peer-review Report	31249-Peer-review(s).pdf
Scientific Misconduct Check	31249-Scientific misconduct check.pdf
Scientific Editor Work List	31249-Scientific editor work list.pdf