Publication Name	World Journal of Gastroenterology
Manuscript ID	31315
Country	China

Received	2016-11-13 10:25
Peer-Review Started	2016-11-13 13:10
To Make the First Decision	2016-12-19 10:45
Return for Revision	2016-12-19 16:05
Revised	2017-01-07 22:18
Second Decision	2017-02-15 21:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-17 13:08
Articles in Press	2017-02-17 13:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-03-02 10:56
Typeset the Manuscript	2017-03-13 14:53
Publish the Manuscript Online	2017-03-19 18:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Hui Ni, Li-Juan Huo and Ting-Ting Li
Funding Agency and Grant Number
Corresponding Author	Li-Juan Huo, MD, Department of Gastroenterology, First Hospital of Shanxi Medical University, 85 South JieFang Road, Taiyuan 030001, Shanxi Province, China. mymail5296@163.com
Key Words	Interleukin-22; Alcoholic liver fibrosis; Hepatic stellate cells; Nrf2; Oxidative stress
Core Tip	We successfully established an in vitro cell model of alcoholic liver fibrosis (ALF). We investigated the influence of interleukin (IL)-22 on ALF and the possible mechanism involved. To our knowledge, this is the first study to confirm the inhibitory effect of IL-22 on ALF at the cellular level. We found that the effect was at least partly related to promotion of nuclear translocation of nuclear factor-related factor (Nrf)2 and increased activity of the antioxidant axis Nrf2-keap1-ARE. We aimed to provide a new target for research on ALF and new drug development.
Publish Date	2017-03-19 18:45
Citation	Ni YH, Huo LJ, Li TT. Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22. World J Gastroenterol 2017; 23(11): 2002-2011
URL	http://www.wjgnet.com/1007-9327/full/v23/i11/2002.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i11.2002

Full Article (PDF)	WJG-23-2002.pdf
Full Article (Word)	WJG-23-2002.doc
Manuscript File	31315-Review.docx
Answering Reviewers	31315-Answering reviewers.pdf
Audio Core Tip	31315-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	31315-Conflict-of-interest statement.pdf
Copyright License Agreement	31315-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	31315-Language certificate.pdf
Peer-review Report	31315-Peer-review(s).pdf
Scientific Misconduct Check	31315-Scientific misconduct check.pdf
Scientific Editor Work List	31315-Scientific editor work list.pdf