| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Raluca Niculina Ciurea, Ion Rogoveanu, Daniel Pirici, Georgică-Costinel Târtea, Costin Teodor Streba, Cristina Florescu, Bogdan Cătălin, Ileana Puiu, Elena-Anca Târtea and Cristin Constantin Vere |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Romanian National Authority for Scientific Research and Innovation, CNCS – UEFISCDI |
PN-II-RU-TE-2014-4-0582 |
|
| Corresponding Author |
Georgică-Costinel Târtea, MD, PhD, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Petru Rareș Street 2, 200349 Craiova, Romania. georgetartea@gmail.com
|
| Key Words |
Beta-2 adrenergic receptors; Enteric nervous system; Colorectal adenocarcinoma; Spectral unmixing immunohistochemistry; Tumor grading |
| Core Tip |
In the present study, we provide the first description of beta-2 adrenergic (B2A) receptors found on the nuclear membrane of colon adenocarcinoma cells. B2A receptors have a high level of expression in the neoplastic cells from colorectal adenocarcinoma, and a significant association was found between the expression of B2A receptors and tumor grading. Regarding the enteric nervous system and its associations with colorectal cancer, we observed a decrease of the relative area, both for Auerbach and Meissner plexuses, with the increase of the tumor grading, and an increase of the relative area of other nervous elements with the tumor grading.
|
| Publish Date |
2017-02-20 17:58 |
| Citation |
Ciurea RN, Rogoveanu I, Pirici D, Târtea GC, Streba CT, Florescu C, Cătălin B, Puiu I, Târtea EA, Vere CC. B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma. World J Gastroenterol 2017; 23(7): 1250-1261 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i7/1250.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i7.1250 |
