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Articles Published Processes
3/13/2017 7:05:00 PM | Browse: 1095 | Download: 2042
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Received |
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2016-11-11 09:10 |
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Peer-Review Started |
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2016-11-13 14:04 |
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To Make the First Decision |
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2016-12-19 10:46 |
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Return for Revision |
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2016-12-19 15:56 |
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Revised |
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2016-12-27 20:59 |
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Second Decision |
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2017-01-06 13:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-01-11 12:16 |
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Articles in Press |
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2017-01-11 12:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-03-07 10:56 |
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Publish the Manuscript Online |
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2017-03-13 19:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fabio Marongiu, Michela Marongiu, Antonella Contini, Monica Serra, Erika Cadoni, Riccardo Murgia and Ezio Laconi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Italian Association for Cancer Research |
IG 14640 |
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| Corresponding Author |
Fabio Marongiu, PhD, Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, Via Porcell 4, IV floor, 09124 Cagliari,
Italy. fabiomarongiu@unica.it
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| Key Words |
Liver regeneration; Hypertrophy; Hyperplasia |
| Core Tip |
The ability of the liver to regenerate is remarkable on both clinical and biological grounds. It is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system during the regenerative response elicited by 2/3 partial hepatectomy (PH) in rats. Analysis of cluster size distribution revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes returned to control values throughout the regenerative process. Thus, hyperplasia stands as the major mechanism contributing to liver mass restoration after PH.
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| Publish Date |
2017-03-13 19:06 |
| Citation |
Marongiu F, Marongiu M, Contini A, Serra M, Cadoni E, Murgia R, Laconi E. Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection. World J Gastroenterol 2017; 23(10): 1764-1770 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i10/1764.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i10.1764 |
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