Publication Name	World Journal of Hepatology
Manuscript ID	31379
Country	United States

Received	2016-11-14 09:29
Peer-Review Started	2016-11-15 10:52
To Make the First Decision	2016-12-01 09:07
Return for Revision	2016-12-01 11:03
Revised	2016-12-15 07:48
Second Decision	2017-01-04 16:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 14:14
Articles in Press	2017-01-14 14:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-13 17:39
Publish the Manuscript Online	2017-02-17 08:32

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Addition of simvastatin to carvedilol non responders: A new pharmacological therapy for treatment of portal hypertension
Manuscript Source	Unsolicited Manuscript
All Author List	Zeeshan Ahmad Wani, Sonmoon Mohapatra, Afaq Ahmad Khan, Ashutosh Mohapatra and Ghulam Nabi Yatoo
Funding Agency and Grant Number
Corresponding Author	Sonmoon Mohapatra, MD, Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School/Saint Peters University Hospital, 254 Easton Ave, New Brunswick, NJ 08901, United States. sonmoon0mohapatra@gmail.com
Key Words	Simvastatin; Cirrhosis; Carvedilol; Liver cirrhosis; Portal hypertension; Hepatocellular carcinoma
Core Tip	There is no pharmacological option available for treatment of carvedilol nonresponders in patients with portal hypertension. Addition of simvastatin could be an important pharmacological rescue therapy for carvedilol nonresponders. This study showed that addition of simvastatin to carvedilol non responders can increase overall response to around 80%, which is one of the best possible pharmacologically produced chronic response and it opens a new strategy for portal hypertension treatment.
Publish Date	2017-02-17 08:32
Citation	Wani ZA, Mohapatra S, Khan AA, Mohapatra A, Yatoo GN. Addition of simvastatin to carvedilol non responders: A new rescue therapy for treatment of portal hypertension. World J Hepatol 2017; 9(5): 270-277
URL	http://www.wjgnet.com/1948-5182/full/v9/i5/270.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i5.270

Full Article (PDF)	WJH-9-270.pdf
Full Article (Word)	WJH-9-270.doc
Manuscript File	31379-Review.docx
Answering Reviewers	31379-Answering reviewers.pdf
Audio Core Tip	31379-Audio core tip.mp3
Biostatistics Review Certificate	31379-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31379-Conflict-of-interest statement.pdf
Copyright License Agreement	31379-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161113213427.doc
Institutional Review Board Approval Form or Document	31379-Institutional review board statement.pdf
Peer-review Report	31379-Peer-review(s).pdf
Scientific Misconduct Check	31379-Scientific misconduct check.pdf
Scientific Editor Work List	31379-Scientific editor work list.pdf