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Articles Published Processes
4/6/2017 6:30:00 PM | Browse: 1288 | Download: 2625
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Received |
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2016-11-16 10:12 |
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Peer-Review Started |
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2016-11-17 17:04 |
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To Make the First Decision |
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2016-12-19 09:53 |
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Return for Revision |
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2016-12-24 17:44 |
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Revised |
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2017-01-05 21:54 |
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Second Decision |
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2017-03-01 11:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 16:53 |
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Articles in Press |
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2017-03-02 16:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-11 15:32 |
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Typeset the Manuscript |
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2017-03-24 16:04 |
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Publish the Manuscript Online |
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2017-04-06 18:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cullin 4A is associated with epithelial to mesenchymal transition and poor prognosis in perihilar cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tong-Jun Zhang, Dong Xue, Cheng-De Zhang, Ze-Dong Zhang, Qing-Ran Liu and Jian-Qiang Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dong Xue, MD, PhD, Department of General Surgery, The People’s Hospital of Binzhou, No. 515, Seventh Huanghe Road, Binzhou 256610, Shandong Province, China. xdbzsurgeon@163.com |
| Key Words |
Perihilar cholangiocarcinoma; Epithelial to mesenchymal transition; ZEB1; Cullin 4A; Metastasis; Prognosis |
| Core Tip |
Cullin 4A (CUL4A), a core subunit of E3 ubiquitin ligase, was confirmed to promote the meta¬stasis and the epithelial to mesenchymal transition (EMT) in perihilar cholangiocarcinoma (PHCC) in the present study. High CUL4A expression was revealed to be correlated with poor overall survival (OS) and progression-free survival (PFS) of PHCC patients. CUL4A expression was detected to be the only independent risk factor for OS and PFS in PHCC. Mechanistically, ZEB1 was verified to mediate the function of CUL4A in regulating PHCC metastasis and the EMT. |
| Publish Date |
2017-04-06 18:30 |
| Citation |
Zhang TJ, Xue D, Zhang CD, Zhang ZD, Liu QR, Wang JQ. Cullin 4A is associated with epithelial to mesenchymal transition and poor prognosis in perihilar cholangiocarcinoma. World J Gastroenterol 2017; 23(13): 2318-2329 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i13/2318.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i13.2318 |
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