Publication Name	World Journal of Gastroenterology
Manuscript ID	31434
Country	Japan

Received	2016-11-16 11:06
Peer-Review Started	2016-11-16 17:29
To Make the First Decision	2016-12-19 11:30
Return for Revision	2016-12-20 11:25
Revised	2017-01-25 09:59
Second Decision	2017-03-01 11:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-02 17:10
Articles in Press	2017-03-02 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-03-19 07:02
Typeset the Manuscript	2017-04-08 20:24
Publish the Manuscript Online	2017-04-20 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis B virus infection and alcohol consumption
Manuscript Source	Invited Manuscript
All Author List	Ayako Iida-Ueno, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
Funding Agency and Grant Number
Corresponding Author	Dr. Masaru Enomoto, Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. enomoto-m@med.osaka-cu.ac.jp
Key Words	Entecavir; Genetic factors; Hepatocellular carcinoma; Interferon
Core Tip	The mechanisms by which alcohol enhances disease progression are less well understood in chronic hepatitis B than in chronic hepatitis C. The association of light-to-moderate alcohol consumption with clinical outcomes in patients with chronic hepatitis B virus (HBV) infection appears modest. Although the threshold amount of alcohol for increasing hepatocellular car­cinoma (HCC) risk remains unknown, heavy alcohol consumption significantly accelerates the progression of liver disease to cirrhosis and, ultimately, HCC. Alcohol abuse could impair the response to interferon-α therapy in chronic hepatitis B patients, although not fully confirmed, and can increase the risk of HCC even in patients with low HBV DNA levels during nucleoside/nucleotide therapy.
Publish Date	2017-04-20 15:58
Citation	Iida-Ueno A, Enomoto M, Tamori A, Kawada N. Hepatitis B virus infection and alcohol consumption. World J Gastroenterol 2017; 23(15): 2651-2659
URL	http://www.wjgnet.com/1007-9327/full/v23/i15/2651.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i15.2651

Full Article (PDF)	WJG-23-2651.pdf
Full Article (Word)	WJG-23-2651.doc
Manuscript File	31434-Review.doc
Answering Reviewers	31434-Answering reviewers.pdf
Audio Core Tip	31434-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31434-Conflict-of-interest statement.pdf
Copyright License Agreement	31434-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20161116093734.pdf
Peer-review Report	31434-Peer-review(s).pdf
Scientific Misconduct Check	31434-Scientific misconduct check.pdf
Scientific Editor Work List	31434-Scientific editor work list.pdf