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Articles Published Processes
3/24/2017 10:31:00 AM | Browse: 938 | Download: 1569
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Received |
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2016-11-18 10:31 |
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Peer-Review Started |
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2016-11-22 10:01 |
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To Make the First Decision |
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2017-01-14 12:01 |
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Return for Revision |
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2017-01-16 21:00 |
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Revised |
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2017-01-21 21:43 |
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Second Decision |
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2017-02-23 18:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-13 12:14 |
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Articles in Press |
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2017-03-13 12:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-03-20 09:11 |
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Publish the Manuscript Online |
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2017-03-24 10:35 |
| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dermatology |
| Manuscript Type |
Observational Study |
| Article Title |
Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report
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| Manuscript Source |
Invited Manuscript |
| All Author List |
TN Shiny, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Ritu Rawat and Rajni Sharma |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Vikram K Mahajan, MBBS, MD, Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Tanda Hospital Rd, Kangra, Himachal Pradesh 176001, India. vkm1@rediffmail.com |
| Key Words |
Anticonvulsant hypersensitivity syndrome; Carbamazepine; Sodium valproate; Drug rash with eosinophilia with or without systemic involvement; Drug patch test; Lamotrigine; Phenobarbitone; Phenytoin; Stevens-Johnsons syndrome; Toxic epidermal necrolysis |
| Core Tip |
Anticonvulsants account for 20% of all adverse cutaneous drug reactions (ACDRs) while cross-reactions occur frequently among carbamazepine, phenytoin, phenobarbitone necessitating careful prescriptions. The clinical presentation alone is not diagnostic and identification of offending drug needs causality assessment that may be misleading in patients on multiple medications. Drug provocation, skin prick or intradermal tests have ethical issues for possibility of precipitating more severe reactions. Basophil degranulation/lymphocyte activation or drug specific IgE radioallergosorbent tests, histamine release and passive haemagglutination tests have limited use in clinical practice. Drug patch testing appears useful in anticonvulsant ACDRs, drug imputability and cross-reactions established clinically. |
| Publish Date |
2017-03-24 10:35 |
| Citation |
Shiny TN, Mahajan VK, Mehta KS, Chauhan PS, Rawat R, Sharma R. Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report. World J Methodol 2017; 7(1): 25-32 |
| URL |
http://www.wjgnet.com/2222-0682/full/v7/i1/25.htm |
| DOI |
http://dx.doi.org/10.5662/wjm.v7.i1.25 |
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