Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	31448
Country	Australia

Received	2016-11-21 14:06
Peer-Review Started	2016-11-22 10:01
To Make the First Decision	2016-12-29 08:35
Return for Revision	2016-12-30 10:12
Revised	2017-05-24 06:56
Second Decision	2017-07-06 09:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-17 06:15
Articles in Press	2017-07-17 06:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-03 03:51
Publish the Manuscript Online	2017-08-14 01:56

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa
Manuscript Source	Invited Manuscript
All Author List	John M Hutson, Pam J Farmer, Cristal J Peck, Chung W Chow and Bridget R Southwell
Funding Agency and Grant Number
Corresponding Author	Bridget R Southwell , GI Motility/Surgical Research Group, Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville 3052, Australia. bridget.southwell@mcri.edu.au
Key Words	Enteric nervous system; RET; Neuroganglioma; MEN2B
Core Tip	Multiple endocrine neoplasia (MEN) 2B is a rare anomaly caused by an activating mutation of the RET known to produce enteric gangliomatosis. Thyroidectomy is performed to avoid cancer and the colon removed to overcome the constipation. This child presented with constipation very early (1-mo-old) and had subtotal colectomy at 4 years. The classes of nerves affected in MEN2B colon have not been studied before. We used immunohistochemistry with multiple antibodies. There was a massive increase in intrinsic nerve fibres in myenteric and submucosal ganglia, with a differential increase in types of nerve fibres in the muscle and mucosa.
Publish Date	2017-08-14 01:56
Citation	Hutson JM, Farmer PJ, Peck CJ, Chow CW, Southwell BR. Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa. World J Gastrointest Pathophysiol 2017; 8(3): 142-149
URL	http://www.wjgnet.com/2150-5330/full/v8/i3/142.htm
DOI	http://dx.doi.org/10.4291/wjgp.v8.i3.142

Full Article (PDF)	WJGP-8-142.pdf
Full Article (Word)	WJGP-8-142.doc
Manuscript File	31448-Review.doc
Answering Reviewers	31448-Answering reviewers.pdf
Audio Core Tip	31448-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	31448-Conflict-of-interest statement.pdf
Copyright License Agreement	31448-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20161117071037.pdf
Peer-review Report	31448-Peer-review(s).pdf
Scientific Misconduct Check	31448-Scientific misconduct check.pdf
Scientific Editor Work List	31448-Scientific editor work list.pdf