| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hiroki Morita, Erito Mochiki, Nobuyuki Takahashi, Kiyoshi Kawamura, Akira Watanabe, Toshinaga Sutou, Atsushi Ogawa, Mitsuhiro Yanai, Kyoichi Ogata, Takaaki Fujii, Tetsuro Ohno, Souichi Tsutsumi, Takayuki Asao and Hiroyuki Kuwano |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Hiroki Morita, MD, PhD, Department of General Surgical Science (Surgery 1), Gunma University, Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. m09702031@gunma-u.ac.jp |
| Key Words |
5-hydroxytryptamine receptor antagonist; Colonic motility; Irritable bowel syndrome |
| Core Tip |
Previous studies have investigated the effects of 5-hydroxytryptamine (5-HT) receptor antagonists on abnormal colonic motor activity, following either the administration of 5-HT or stress induction. This study is the first to investigate the effects of 5-HT receptor antagonists on normal colonic motor activity in dogs. 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity. A 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. 5-HT3 and 5-HT4 receptor antagonists may also be used as premedications for colonoscopy. A 5-HT2B receptor antagonist may be used for the treatment of diarrhea-predominant irritable bowel syndrome without the side effect of constipation. |
| Publish Date |
2013-11-08 14:06 |
| Citation |
Morita H, Mochiki E, Takahashi N, Kawamura K, Watanabe A, Sutou T, Ogawa A, Yanai M, Ogata K, Fujii T, Ohno T, Tsutsumi S, Asao T, Kuwano H. Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs. World J Gastroenterol 2013; 19(39): 6604-6612 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i39/6604.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i39.6604 |
