Publication Name	World Journal of Gastroenterology
Manuscript ID	3145
Country	Japan

Received	2013-04-11 07:46
Peer-Review Started	2013-04-12 12:00
First Decision by Editorial Office Director
Return for Revision	2013-07-17 10:05
Revised	2013-08-12 16:00
Publication Fee Transferred
Second Decision by Editor	2013-09-16 17:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-09-17 06:05
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-11 18:31
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs
Manuscript Source	Invited Manuscript
All Author List	Hiroki Morita, Erito Mochiki, Nobuyuki Takahashi, Kiyoshi Kawamura, Akira Watanabe, Toshinaga Sutou, Atsushi Ogawa, Mitsuhiro Yanai, Kyoichi Ogata, Takaaki Fujii, Tetsuro Ohno, Souichi Tsutsumi, Takayuki Asao and Hiroyuki Kuwano
Funding Agency and Grant Number
Corresponding Author	Hiroki Morita, MD, PhD, Department of General Surgical Science (Surgery 1), Gunma University, Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. m09702031@gunma-u.ac.jp
Key Words	5-hydroxytryptamine receptor antagonist; Colonic motility; Irritable bowel syndrome
Core Tip	Previous studies have investigated the effects of 5-hydroxytryptamine (5-HT) receptor antagonists on abnormal colonic motor activity, following either the administration of 5-HT or stress induction. This study is the first to investigate the effects of 5-HT receptor antagonists on normal colonic motor activity in dogs. 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity. A 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. 5-HT3 and 5-HT4 receptor antagonists may also be used as premedications for colonoscopy. A 5-HT2B receptor antagonist may be used for the treatment of diarrhea-predominant irritable bowel syndrome without the side effect of constipation.
Publish Date	2013-11-08 14:06
Citation	Morita H, Mochiki E, Takahashi N, Kawamura K, Watanabe A, Sutou T, Ogawa A, Yanai M, Ogata K, Fujii T, Ohno T, Tsutsumi S, Asao T, Kuwano H. Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs. World J Gastroenterol 2013; 19(39): 6604-6612
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6604.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6604

Full Article (PDF)	WJG-19-6604.pdf
Manuscript File	3145-Review.docx
Answering Reviewers	3145-Answering reviewers.pdf
Copyright License Agreement	3145-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3145-Language certificate.pdf
Peer-review Report	3145-Peer reviewer(s).pdf
Scientific Editor Work List	3145-Scientific editor work list.doc