Publication Name	World Journal of Hepatology
Manuscript ID	31568
Country	Italy

Received	2016-11-25 10:30
Peer-Review Started	2016-11-27 16:54
To Make the First Decision	2017-01-14 11:19
Return for Revision	2017-01-16 17:41
Revised	2017-01-26 23:50
Second Decision	2017-02-08 15:41
Accepted by Journal Editor-in-Chief	2017-02-08 20:11
Accepted by Executive Editor-in-Chief	2017-02-20 15:08
Articles in Press	2017-02-20 15:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-20 11:53
Publish the Manuscript Online	2017-03-24 09:18

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness
Manuscript Source	Invited Manuscript
All Author List	Simone Brivio, Massimiliano Cadamuro, Mario Strazzabosco and Luca Fabris
Funding Agency and Grant Number
Corresponding Author	Luca Fabris, MD, PhD, Department of Molecular Medicine, University of Padua School of Medicine, Viale G. Colombo 3, 35131 Padua, Italy. luca.fabris@unipd.it
Key Words	Tumor microenvironment; Desmoplasia; Cancer-associated fibroblast; Inflammation; Tumor-associated macrophage; Lymphatic endothelial cell; Mesenchymal stem cell; Extracellular matrix
Core Tip	Cholangiocarcinoma (CCA) is a typically worrisome malignancy, whose incidence has been steadily increasing. In CCA, as cancerous lesions are emerging, the surrounding stroma gradually under-goes a pathological remodeling, eventually becoming a paramount determinant of tumor growth and dissemination. Indeed, the different cell types populating the tumor microenvironment, also referred to as tumor reactive stroma, enable CCA cells to develop an agg-ressive phenotype, due to the secretion of a multitude of soluble factors. Therefore, functional insights into the harmful relationship between cancer and reactive stromal cells are of utmost importance, in order to unveil novel molecular targets amenable of therapeutic intervention.
Publish Date	2017-03-24 09:18
Citation	Brivio S, Cadamuro M, Strazzabosco M, Fabris L. Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggre­ssiveness. World J Hepatol 2017; 9(9): 455-468
URL	http://www.wjgnet.com/1948-5182/full/v9/i9/455.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i9.455

Full Article (PDF)	WJH-9-455.pdf
Full Article (Word)	WJH-9-455.doc
Manuscript File	31568-Review.docx
Answering Reviewers	31568-Answering reviewers.pdf
Audio Core Tip	31568-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31568-Conflict-of-interest statement.pdf
Copyright License Agreement	31568-Copyright assignment.pdf
Peer-review Report	31568-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31568-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31568-Scientific misconduct check.pdf
Scientific Editor Work List	31568-Scientific editor work list.pdf