Publication Name	World Journal of Gastroenterology
Manuscript ID	31570
Country	Germany

Received	2016-11-25 10:26
Peer-Review Started	2016-11-27 15:42
To Make the First Decision	2016-12-19 09:54
Return for Revision	2016-12-24 19:23
Revised	2017-01-06 19:44
Second Decision	2017-02-15 18:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-17 10:07
Articles in Press	2017-02-17 10:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-27 20:28
Publish the Manuscript Online	2017-03-06 13:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers
Manuscript Source	Invited Manuscript
All Author List	Elke Cario
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft CA226/4-3
Corresponding Author	Elke Cario, MD, Professor, Experimental Gastroenterology, Department of Gastroenterology and Hepatology, University Hospital Essen, Medical School, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, 45147 Essen, Germany. elke.cario@uni-due.de
Key Words	Inflammatory bowel diseases; Multidrug resistance; Innate immunity; Microbiota; Xenobiotics
Core Tip	Altered levels of p-glycoprotein (p-gp) expression as well as genetic variants of ABCB1/MDR1 have been associated with inflammatory bowel diseases (IBD). Decreased efflux activity of p-gp may promote disease susceptibility, while increased efflux activity may impair drug responses in IBD. In this Editorial, I highlight what we need to know about this transporter and xenobiotic signaling pathways in order to better understand its potential pathophysiology in IBD and develop targeted therapies.
Publish Date	2017-03-06 13:24
Citation	Cario E. P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers. World J Gastroenterol 2017; 23(9): 1513-1520
URL	http://www.wjgnet.com/1007-9327/full/v23/i9/1513.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i9.1513

Full Article (PDF)	WJG-23-1513.pdf
Full Article (Word)	WJG-23-1513.doc
Manuscript File	31570-Review.docx
Answering Reviewers	31570-Answering reviewers.pdf
Audio Core Tip	31570-Audio core tip.wma
Conflict-of-Interest Disclosure Form	31570-Conflict-of-interest statement.pdf
Copyright License Agreement	31570-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31570-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20161124193519.pdf
Peer-review Report	31570-Peer-review(s).pdf
Scientific Misconduct Check	31570-Scientific misconduct check.pdf
Scientific Editor Work List	31570-Scientific editor work list.pdf