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3/6/2017 1:27:00 PM | Browse: 337 | Download: 415
Publication Name World Journal of Gastroenterology
Manuscript ID 31570
Country/Territory Germany
Received
2016-11-25 10:26
Peer-Review Started
2016-11-27 15:42
To Make the First Decision
2016-12-19 09:54
Return for Revision
2016-12-24 19:23
Revised
2017-01-06 19:44
Second Decision
2017-02-15 18:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-17 10:07
Articles in Press
2017-02-17 10:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-02-27 20:28
Publish the Manuscript Online
2017-03-06 13:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers
Manuscript Source Invited Manuscript
All Author List Elke Cario
Funding Agency and Grant Number
Funding Agency Grant Number
Deutsche Forschungsgemeinschaft CA226/4-3
Corresponding author Elke Cario, MD, Professor, Experimental Gastroenterology, Department of Gastroenterology and Hepatology, University Hospital Essen, Medical School, University of Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, 45147 Essen, Germany. elke.cario@uni-due.de
Keywords Inflammatory bowel diseases; Multidrug resistance; Innate immunity; Microbiota; Xenobiotics
Core Tip Altered levels of p-glycoprotein (p-gp) expression as well as genetic variants of ABCB1/MDR1 have been associated with inflammatory bowel diseases (IBD). Decreased efflux activity of p-gp may promote disease susceptibility, while increased efflux activity may impair drug responses in IBD. In this Editorial, I highlight what we need to know about this transporter and xenobiotic signaling pathways in order to better understand its potential pathophysiology in IBD and develop targeted therapies.
Publish Date 2017-03-06 13:24
Citation Cario E. P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers. World J Gastroenterol 2017; 23(9): 1513-1520
Url http://www.wjgnet.com/1007-9327/full/v23/i9/1513.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i9.1513
Full Article (PDF) WJG-23-1513.pdf
Full Article (Word) WJG-23-1513.doc
Manuscript File 31570-Review.docx
Answering Reviewers 31570-Answering reviewers.pdf
Audio Core Tip 31570-Audio core tip.wma
Conflict-of-Interest Disclosure Form 31570-Conflict-of-interest statement.pdf
Copyright License Agreement 31570-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31570-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20161124193519.pdf
Peer-review Report 31570-Peer-review(s).pdf
Scientific Misconduct Check 31570-Scientific misconduct check.pdf
Scientific Editor Work List 31570-Scientific editor work list.pdf