Publication Name	World Journal of Gastroenterology
Manuscript ID	3158
Country	France

Received	2013-04-11 08:44
Peer-Review Started	2013-04-11 20:15
To Make the First Decision	2013-07-19 08:51
Return for Revision	2013-07-22 15:41
Revised	2013-08-07 18:03
Second Decision	2013-09-16 17:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-06 09:56
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles
Manuscript Source	Invited Manuscript
All Author List	Sébastien Küry, Céline Garrec, Fabrice Airaud, Flora Breheret, Virginie Guibert, Cécile Frenard, Shuo Jiao, Dominique Bonneau, Pascaline Berthet, Céline Bossard, Olivier Ingster, Estelle Cauchin and Stéphane Bezieau
Funding Agency and Grant Number
Corresponding Author	Sébastien Küry, DVM, PhD, CHU Nantes, Service de Génétique Médicale, 9 quai Moncousu, 44093 Nantes CEDEX 1, France. sebastien.kury@chu-nantes.fr
Key Words	Colorectal cancer; UNC5C; Genetic predisposition; Familial study; Association study; Low risk
Core Tip	UNC5C was recently described as a new gene potentially predisposing to familial forms of colorectal cancer (CRC). In order to evaluate the risk of CRC associated with the variants of UNC5C exon 11 suggested to underlie this predisposition, we screened both patients with familial CRC forms of hitherto unknown etiology, and patients with sporadic CRCs. Overall, we confirm that UNC5C mutations are very rare in familial and sporadic forms of CRC. Further identifications of families with UNC5C mutations are needed to justify routine UNC5C testing in patients with CRC or gastric cancer for potential genetic counseling purposes.
Publish Date	2014-01-20 17:10
Citation	Küry S, Garrec C, Airaud F, Breheret F, Guibert V, Frenard C, Jiao S, Bonneau D, Berthet P, Bossard C, Ingster O, Cauchin E, Bezieau S. Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles. World J Gastroenterol 2014; 20(1): 204-213
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/204.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.204

Full Article (PDF)	WJG-20-204.pdf
Full Article (Word)	WJG-20-204.doc
Manuscript File	3158-Review.doc
Answering Reviewers	3158-Answering reviewers.pdf
Copyright License Agreement	3158-Copyright assignment.docx
Institutional Review Board Approval Form or Document	Ethics committee approval.pdf
Non-Native Speakers of English Editing Certificate	3158-Language certificate.docx
Peer-review Report	3158-Peer reviewer(s).pdf
Scientific Editor Work List	3158-Scientific editor work list.doc