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5/18/2017 4:11:31 AM | Browse: 1487 | Download: 1721
Publication Name World Journal of Biological Chemistry
Manuscript ID 31581
Country/Territory France
Received
2016-11-26 21:59
Peer-Review Started
2016-11-29 08:19
To Make the First Decision
2017-01-14 11:19
Return for Revision
2017-01-16 18:00
Revised
2017-01-24 18:38
Second Decision
2017-02-08 15:42
Accepted by Journal Editor-in-Chief
2017-02-08 21:42
Accepted by Company Editor-in-Chief
2017-02-20 15:10
Articles in Press
2017-02-20 15:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-16 01:41
Publish the Manuscript Online
2017-05-18 04:11
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Minireviews
Article Title Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity
Manuscript Source Invited Manuscript
All Author List Luciano Pirola and José Candido Ferraz
Funding Agency and Grant Number
Funding Agency Grant Number
CAPES/COFECUB Me-797-14
Corresponding Author Dr. Luciano Pirola, INSERM Unit 1060, South Lyon Hospital, Medical Faculty, 165 Ch. du Grand Revoyet - BP12, 69921 Oullins, France. luciano.pirola@univ-lyon1.fr
Key Words Type 2 diabetes; Crown-like structures; Adipose tissue inflammation; Macrophages; Eosinophils; Obesity
Core Tip Low-grade inflammation of adipose tissue (AT) contributes to insulin resistance and type 2 diabetes in obese patients. On the contrary, in lean individuals, the immune environment of AT is non-inflammatory. In obesity, AT is infiltrated by pro-inflammatory macrophages and T cells leading to the accumulation of interleukin-1b, IL-1b), tumor necrosis factor a, IL-17 and IL-6. On the contrary, M2 macrophages, Th2 and T-regs cells producing anti-inflammatory IL-10, IL-5 and interferon-γ, are present in AT of lean individuals. Here, we discuss the interaction between AT and infiltrating immune cells in the lean vs the obese condition, with emphasis on the contribution of pro- and anti-inflammatory cytokines to the establishment of insulin resistance.
Publish Date 2017-05-18 04:11
Citation Pirola L, Ferraz JC. Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity. World J Biol Chem 2017; 8(2): 120-128
URL http://www.wjgnet.com/1949-8454/full/v8/i2/120.htm
DOI http://dx.doi.org/10.4331/wjbc.v8.i2.120
Full Article (PDF) WJBC-8-120.pdf
Full Article (Word) WJBC-8-120.doc
Manuscript File 31581-Review.doc
Answering Reviewers 31581-Answering reviewers.pdf
Audio Core Tip 31581-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31581-Conflict-of-interest statement.pdf
Copyright License Agreement 31581-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31581-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161125222237.docx
Non-Native Speakers of English Editing Certificate 31581-Language certificate.pdf
Peer-review Report 31581-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 31581-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 31581-Scientific misconduct check.pdf
Scientific Editor Work List 31581-Scientific editor work list.pdf