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Articles Published Processes
5/18/2017 4:11:31 AM | Browse: 1642 | Download: 2132
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Received |
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2016-11-26 21:59 |
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Peer-Review Started |
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2016-11-29 08:19 |
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To Make the First Decision |
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2017-01-14 11:19 |
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Return for Revision |
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2017-01-16 18:00 |
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Revised |
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2017-01-24 18:38 |
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Second Decision |
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2017-02-08 15:42 |
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Accepted by Journal Editor-in-Chief |
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2017-02-08 21:42 |
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Accepted by Executive Editor-in-Chief |
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2017-02-20 15:10 |
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Articles in Press |
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2017-02-20 15:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-16 01:41 |
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Publish the Manuscript Online |
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2017-05-18 04:11 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Luciano Pirola and José Candido Ferraz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAPES/COFECUB |
Me-797-14 |
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| Corresponding Author |
Dr. Luciano Pirola, INSERM Unit 1060, South Lyon Hospital, Medical Faculty, 165 Ch. du Grand Revoyet - BP12, 69921 Oullins, France. luciano.pirola@univ-lyon1.fr |
| Key Words |
Type 2 diabetes; Crown-like structures; Adipose tissue inflammation; Macrophages; Eosinophils; Obesity |
| Core Tip |
Low-grade inflammation of adipose tissue (AT) contributes to insulin resistance and type 2 diabetes in obese patients. On the contrary, in lean individuals, the immune environment of AT is non-inflammatory. In obesity, AT is infiltrated by pro-inflammatory macrophages and T cells leading to the accumulation of interleukin-1b, IL-1b), tumor necrosis factor a, IL-17 and IL-6. On the contrary, M2 macrophages, Th2 and T-regs cells producing anti-inflammatory IL-10, IL-5 and interferon-γ, are present in AT of lean individuals. Here, we discuss the interaction between AT and infiltrating immune cells in the lean vs the obese condition, with emphasis on the contribution of pro- and anti-inflammatory cytokines to the establishment of insulin resistance. |
| Publish Date |
2017-05-18 04:11 |
| Citation |
Pirola L, Ferraz JC. Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity. World J Biol Chem 2017; 8(2): 120-128 |
| URL |
http://www.wjgnet.com/1949-8454/full/v8/i2/120.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v8.i2.120 |
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