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Articles Published Processes
7/20/2017 10:12:50 AM | Browse: 1326 | Download: 2438
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Received |
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2016-11-27 13:59 |
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Peer-Review Started |
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2016-11-28 20:10 |
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To Make the First Decision |
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2017-01-19 13:54 |
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Return for Revision |
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2017-01-20 15:53 |
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Revised |
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2017-02-18 04:10 |
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Second Decision |
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2017-05-27 01:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-01 08:49 |
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Articles in Press |
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2017-06-01 08:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-06-20 03:00 |
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Typeset the Manuscript |
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2017-07-10 10:04 |
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Publish the Manuscript Online |
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2017-07-20 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhenwu Lin, Zhong Wang, John P Hegarty, Tony R Lin, Yunhua Wang, Sue Deiling, Rongling Wu, Neal J Thomas and Joanna Floros |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Children Miracle Network Research Grant |
132698 |
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| Corresponding Author |
Zhenwu Lin, PhD, Department of Pediatrics, the Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, United States. zxl13@psu.edu |
| Key Words |
Pediatric inflammatory bowel disease; interleukin-10; HO1; Single nucleotide polymorphism; IL10-STAT3 pathway; epistatic interaction |
| Core Tip |
Inflammatory bowel disease (IBD) affects not only adults, but also children and newborn infants. Of the 163 genes currently associated with risk for development of IBD, only a few have been studied in pediatric patients. In this study, we found that one interleukin (IL)-10 genetic variation, rs304496, is associated with risk for pediatric IBD. IL-10 restricts excessive immune responses during intestinal inflammation. We also demonstrated epistatic interactions between genetic variants within the IL-10/STAT3 signaling pathway that contribute to a higher associated risk for pediatric IBD. These findings emphasize the importance of the IL-10 pathway in a subgroup of IBD patients. |
| Publish Date |
2017-07-20 10:12 |
| Citation |
Lin Z, Wang Z, Hegarty JP, Lin TR, Wang Y, Deiling S, Wu R, Thomas NJ, Floros J. Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease. World J Gastroenterol 2017; 23(27): 4897-4909 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i27/4897.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i27.4897 |
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