Publication Name	World Journal of Diabetes
Manuscript ID	3160
Country	United States

Received	2013-04-11 08:01
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2013-04-15 16:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-16 08:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-04 10:42
Publish the Manuscript Online	2013-06-20 15:18

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Toxicology
Manuscript Type	Autobiography
Article Title	Caribbean maitotoxin elevates [Ca2+]i and activates non-selective cation channels in HIT-T15 cells
Manuscript Source	Invited Manuscript
All Author List	Xin-Zhong Lu, Robert Deckey, Guo-Liang Jiao, Hui-Feng Ren and Ming Li
Funding Agency and Grant Number
Corresponding Author	Dr. Ming Li, Department of Physiology, Tulane University, Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, United States. mli@tulane.edu
Key Words	Maitotoxin; Calcium fluorescence; High voltage gated Ca2+ channels; Whole cell patch clamp; Insulin secreting cells
Core Tip	The toxicity of maitotoxin is estimated to affect over 50000 people annually. Baracuda, snapper, grouper, jacks, and moray eel are particularly notorious for their potential to carry high toxin load. The symptoms of the toxicity include numbness of the perioral area and extremities, reversal of temperature sensation, muscle and joint aches, headache, itching tachycardia, hypertension, blurred vision, and paralysis. Our study aims to elucidate the cellular toxic mechanism of caribbean maitotoxin in mammalian cells. We conclude that it causes opening of non-selective, non-voltage activated ion channels, which elevates level of intracellular calcium concentration and leads to cellular toxicities.
Publish Date	2013-06-20 15:18
Citation	Lu XZ, Deckey R, Jiao GL, Ren HF, Li M. Caribbean maitotoxin elevates [Ca2+]i and activates non-selective cation channels in HIT-T15 cells. World J Diabetes 2013; 4(3): 70-75
URL	http://www.wjgnet.com/1948-9358/full/v4/i3/70.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i3.70

Full Article (PDF)	WJD-4-70.pdf
Manuscript File	3160-Review.doc
Answering Reviewers	3160-Answering reviewers.doc
Copyright License Agreement	3160-Copyright assignment.pdf
Peer-review Report	3160-Peer review(s).pdf
Scientific Editor Work List	3160-Scientific editor work list.doc