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Articles Published Processes
3/13/2017 7:05:00 PM | Browse: 1012 | Download: 2121
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Received |
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2016-12-02 10:29 |
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Peer-Review Started |
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2016-12-02 11:09 |
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To Make the First Decision |
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2016-12-19 11:10 |
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Return for Revision |
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2016-12-23 16:57 |
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Revised |
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2017-01-06 19:07 |
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Second Decision |
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2017-01-16 11:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-01-18 11:36 |
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Articles in Press |
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2017-01-18 11:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-02-15 02:34 |
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Typeset the Manuscript |
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2017-03-06 10:06 |
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Publish the Manuscript Online |
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2017-03-13 19:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PNCA
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Fang Hou, Lin-Ping Xu, Hai-Yan Song, Shuai Li, Chen Wu and Ju-Feng Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Public Welfare Project Foundation of Henan Province |
20130010 |
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| Corresponding Author |
Dr. Ju-Feng Wang, Professor, Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Road, Zhengzhou 450008, Henan Province,
China. 13783583966@163.com
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| Key Words |
Esophageal cancer related-gene 2; Cisplatin; Resistance; p53; Proliferating cell nuclear antigen |
| Core Tip |
Cisplatin (DDP) is one of the most effective agents in treating esophageal cancer, but drug resistance poses a major impediment. Combination therapy has become an important method for overcoming drug resistance. This study showed that esophageal cancer-related gene 2 (ECRG2) in combination with DDP can inhibit viability and induce apoptosis in DDP-resistant esophageal cancer cells, possibly via upregulation of p53 expression and downregulation of proliferating cell nuclear antigen expression. These findings suggest that the combination of ECRG2 and DDP may be a promising strategy for the clinical treatment of esophageal cancers that are resistant to DDP.
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| Publish Date |
2017-03-13 19:06 |
| Citation |
Hou XF, Xu LP, Song HY, Li S, Wu C, Wang JF. ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PNCA. World J Gastroenterol 2017; 23(10): 1796-1803 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i10/1796.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i10.1796 |
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