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3/13/2017 7:05:00 PM | Browse: 304 | Download: 485
Publication Name World Journal of Gastroenterology
Manuscript ID 31665
Country of Manuscript Source China
Received
2016-12-02 10:29
Peer-Review Started
2016-12-02 11:09
To Make the First Decision
2016-12-19 11:10
Return for Revision
2016-12-23 16:57
Revised
2017-01-06 19:07
Second Decision
2017-01-16 11:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-18 11:36
Articles in Press
2017-01-18 11:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-02-15 02:34
Typeset the Manuscript
2017-03-06 10:06
Publish the Manuscript Online
2017-03-13 19:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PNCA
Manuscript Source Unsolicited Manuscript
All Author List Xin-Fang Hou, Lin-Ping Xu, Hai-Yan Song, Shuai Li, Chen Wu and Ju-Feng Wang
Funding Agency and Grant Number
Funding Agency Grant Number
the Public Welfare Project Foundation of Henan Province 20130010
Corresponding author Dr. Ju-Feng Wang, Professor, Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 127 Dongming Road, Zhengzhou 450008, Henan Province, China. 13783583966@163.com
Keywords Esophageal cancer related-gene 2; Cisplatin; Resistance; p53; Proliferating cell nuclear antigen
Core Tip Cisplatin (DDP) is one of the most effective agents in treating esophageal cancer, but drug resistance poses a major impediment. Combination therapy has become an important method for overcoming drug resistance. This study showed that esophageal cancer-related gene 2 (ECRG2) in combination with DDP can inhibit viability and induce apoptosis in DDP-resistant esophageal cancer cells, possibly via upregulation of p53 expression and downregulation of proliferating cell nuclear antigen expression. These findings suggest that the combination of ECRG2 and DDP may be a promising strategy for the clinical treatment of esophageal cancers that are resistant to DDP.
Publish Date 2017-03-13 19:06
Citation Hou XF, Xu LP, Song HY, Li S, Wu C, Wang JF. ECRG2 enhances the anti-cancer effects of cisplatin in cisplatin-resistant esophageal cancer cells via upregulation of p53 and downregulation of PNCA. World J Gastroenterol 2017; 23(10): 1796-1803
Url http://www.wjgnet.com/1007-9327/full/v23/i10/1796.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i10.1796
Full Article (PDF) WJG-23-1796.pdf
Full Article (Word) WJG-23-1796.doc
Manuscript File 31665-Review.doc
Answering Reviewers 31665-Answering reviewers.pdf
Audio Core Tip 31665-Audio core tip.m4a
Biostatistics Review Certificate 31665-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31665-Conflict-of-interest statement.pdf
Copyright License Agreement 31665-Copyright assignment.pdf
Data Sharing Statement 31665-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31665-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 31665-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31665-Language certificate.pdf
Scientific Research Process 31665-Scientific research progress.pdf
Peer-review Report 31665-Peer-review(s).pdf
Scientific Misconduct Check 31665-Scientific misconduct check.pdf
Scientific Editor Work List 31665-Scientific editor work list.pdf