Publication Name	World Journal of Clinical Oncology
Manuscript ID	31675
Country	Brazil

Received	2016-12-02 09:56
Peer-Review Started	2016-12-05 08:53
To Make the First Decision	2017-03-27 11:16
Return for Revision	2017-03-28 13:59
Revised	2017-04-05 10:03
Second Decision	2017-04-24 17:46
Accepted by Journal Editor-in-Chief	2017-04-26 17:02
Accepted by Executive Editor-in-Chief	2017-05-05 16:04
Articles in Press	2017-05-05 16:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-26 04:59
Publish the Manuscript Online	2017-06-02 05:29

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Recurrence-free survival as a putative surrogate for overall survival in phase III trials of curative-intent treatment of colorectal liver metastases: Systematic review
Manuscript Source	Invited Manuscript
All Author List	Raphael LC Araujo, Paulo Herman and Rachel P Riechelmann
Funding Agency and Grant Number
Corresponding Author	Raphael LC Araujo, MD, PhD, Department of Upper Gastrointestinal and Hepato-Pancreato-Bliliary Sugery, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP 14784-400, Brazil. raphael.araujo@hcancerbarretos.com.br
Key Words	Colorectal liver metastases; Surgery; Chemotherapy; Clinical trial; Long-term outcomes; Surrogate endpoints
Core Tip	This study addresses a systematic review of curative-intent treatment of colorectal liver metastasis looking for oncologic outcomes. We describe the association between overall survival (OS) and recurrence free survival in the setting of resectable colorectal liver metastases (CRLM). It suggests that recurrence free survival could work as a putative surrogate of OS in this population, avoiding bigger, longer and more resource-consuming trials. We do believe that our model can be useful to better estimate sample size calculations of superiority phase Ⅲ trials of CRLM aiming for OS.
Publish Date	2017-06-02 05:29
Citation	Araujo RLC, Herman P, Riechelmann RP. Recurrence-free survival as a putative surrogate for overall survival in phase III trials of curative-intent treatment of colorectal liver metastases: Systematic review. World J Clin Oncol 2017; 8(3): 266-272
URL	http://www.wjgnet.com/2218-4333/full/v8/i3/266.htm
DOI	http://dx.doi.org/10.5306/wjco.v8.i3.266

Full Article (PDF)	WJCO-8-266.pdf
Full Article (Word)	WJCO-8-266.doc
Manuscript File	31675-Review.docx
Answering Reviewers	31675-Answering reviewers.pdf
Audio Core Tip	31675-Audio core tip.mp3
Biostatistics Review Certificate	31675-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31675-Conflict-of-interest statement.pdf
Copyright License Agreement	31675-Copyright assignment.pdf
Peer-review Report	31675-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31675-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31675-Scientific misconduct check.pdf
Scientific Editor Work List	31675-Scientific editor work list.pdf