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6/7/2017 7:22:42 AM | Browse: 449 | Download: 270
Publication Name World Journal of Gastroenterology
Manuscript ID 31690
Country/Territory China
2016-12-02 09:16
Peer-Review Started
2016-12-06 11:29
To Make the First Decision
2017-01-19 13:31
Return for Revision
2017-01-19 17:37
2017-02-09 17:42
Second Decision
2017-03-01 11:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-02 17:11
Articles in Press
2017-03-02 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-05-03 10:54
Typeset the Manuscript
2017-05-27 02:50
Publish the Manuscript Online
2017-06-07 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway
Manuscript Source Unsolicited Manuscript
All Author List Xian Zhang, Wei Jiang, Ai-Ling Zhou, Min Zhao and Dao-Rong Jiang
Funding Agency and Grant Number
Funding Agency Grant Number
Jiangsu Bureau of Traditional Chinese Medicine YB2015177
Corresponding author Dr. Dao-Rong Jiang, Department of Infectious Diseases, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong 226001, Jiangsu Province, China. jdr@ntu.edu.cn
Key Words Oxymatrine; Acute liver failure; Toll-like receptor 4; Apoptosis
Core Tip The role of oxymatrine (OMT) in inhibiting apoptosis in acute liver failure (ALF) was investigated. OMT pretreatment protected liver cells by improving the liver pathological change and reducing serum aminotransferase in lipopolysaccharide/D-galactosamine-induced ALF in rats. OMT preconditioning down-regulated apoptosis of hepatocytes and ameliorated pathological changes in liver tissue. The levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α and interleukin-1β in the model group increased significantly, and were significantly reduced by OMT pretreatment. OMT pretreatment down-regulated expression of Toll-like receptor (TLR)4 and active caspase-3 and the Bax/Bcl-2 ratio, and up-regulated expression of P-AKTSer473 and P-GSK3βSer9. OMT could inhibit hepatocyte apoptosis through the TLR4/PI3K/Akt/GSK-3β signaling pathway.
Publish Date 2017-06-07 07:22
Citation Zhang X, Jiang W, Zhou AL, Zhao M, Jiang DR. Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway. World J Gastroenterol 2017; 23(21): 3839-3849
Url http://www.wjgnet.com/1007-9327/full/v23/i21/3839.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i21.3839
Full Article (PDF) WJG-23-3839.pdf
Full Article (Word) WJG-23-3839.doc
Manuscript File 31690-Review.doc
Answering Reviewers 31690-Answering reviewers.pdf
Audio Core Tip 31690-Audio core tip.mp3
Copyright License Agreement 31690-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31690-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 31690-Institutional animal care and use committee statement.pdf
Scientific Research Process 31690-Scientific research process.pdf
Peer-review Report 31690-Peer-review(s).pdf
Scientific Misconduct Check 31690-Scientific misconduct check.pdf
Scientific Editor Work List 31690-Scientific editor work list.pdf