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Articles Published Processes
6/7/2017 7:22:42 AM | Browse: 1169 | Download: 1483
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Received |
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2016-12-02 09:16 |
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Peer-Review Started |
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2016-12-06 11:29 |
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To Make the First Decision |
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2017-01-19 13:31 |
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Return for Revision |
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2017-01-19 17:37 |
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Revised |
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2017-02-09 17:42 |
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Second Decision |
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2017-03-01 11:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 17:11 |
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Articles in Press |
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2017-03-02 17:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-05-03 10:54 |
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Typeset the Manuscript |
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2017-05-27 02:50 |
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Publish the Manuscript Online |
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2017-06-07 07:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian Zhang, Wei Jiang, Ai-Ling Zhou, Min Zhao and Dao-Rong Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Bureau of Traditional Chinese Medicine |
YB2015177 |
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| Corresponding Author |
Dr. Dao-Rong Jiang, Department of Infectious Diseases, Affiliated Hospital of Nantong University, No. 20, Xisi Road, Nantong 226001, Jiangsu Province, China. jdr@ntu.edu.cn |
| Key Words |
Oxymatrine; Acute liver failure; Toll-like receptor 4; Apoptosis |
| Core Tip |
The role of oxymatrine (OMT) in inhibiting apoptosis in acute liver failure (ALF) was investigated. OMT pretreatment protected liver cells by improving the liver pathological change and reducing serum aminotransferase in lipopolysaccharide/D-galactosamine-induced ALF in rats. OMT preconditioning down-regulated apoptosis of hepatocytes and ameliorated pathological changes in liver tissue. The levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α and interleukin-1β in the model group increased significantly, and were significantly reduced by OMT pretreatment. OMT pretreatment down-regulated expression of Toll-like receptor (TLR)4 and active caspase-3 and the Bax/Bcl-2 ratio, and up-regulated expression of P-AKTSer473 and P-GSK3βSer9. OMT could inhibit hepatocyte apoptosis through the TLR4/PI3K/Akt/GSK-3β signaling pathway. |
| Publish Date |
2017-06-07 07:22 |
| Citation |
Zhang X, Jiang W, Zhou AL, Zhao M, Jiang DR. Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway. World J Gastroenterol 2017; 23(21): 3839-3849 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i21/3839.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i21.3839 |
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