Publication Name	World Journal of Orthopedics
Manuscript ID	31743
Country	United Kingdom

Received	2016-12-05 09:28
Peer-Review Started	2016-12-06 15:13
To Make the First Decision	2017-01-14 11:20
Return for Revision	2017-01-16 18:13
Revised	2017-01-28 04:58
Second Decision	2017-02-20 16:00
Accepted by Journal Editor-in-Chief	2017-02-23 11:29
Accepted by Executive Editor-in-Chief	2017-03-02 08:37
Articles in Press	2017-03-02 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-09 15:05
Publish the Manuscript Online	2017-05-12 13:42

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Dementia and osteoporosis in a geriatric population: Is there a common link?
Manuscript Source	Invited Manuscript
All Author List	Candice L Downey, Adam Young, Emily F Burton, Simon M Graham, Robert J Macfarlane, Eva-Maria Tsapakis and Eleftherios Tsiridis
Funding Agency and Grant Number
Corresponding Author	Simon M Graham, MBChB, MRCS, Department of Trauma and Orthopaedics, the Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, United Kingdom. simonmatthewgraham@doctors.org.uk
Key Words	Osteoporosis; Fracture; Dementia; Thyroid disease; Alzheimer’s disease; Elderly; Vitamin D; Vitamin K; Calcium; Statins; Alcohol; Sex steroids
Core Tip	A potential pathological link between osteo¬porosis and dementia has been explored in observational studies, but there exists a lack of large scale randomised controlled trials. We hypothesise that dementia and osteoporosis have common yet independent aetiologies. The most compelling evidence lies in the APOE4 allele, a well-established risk factor for Alzheimer’s disease. APOE4 is associated with fracture, independent of dementia and falling. The mechanism behind this is postulated to be reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele. This may be augmented by the nu¬tritional deficiencies associated with dementia, known to include vitamins K and D.
Publish Date	2017-05-12 13:42
Citation	Downey CL, Young A, Burton EF, Graham SM, Macfarlane RJ, Tsapakis EM, Tsiridis E. Dementia and osteoporosis in a geriatric population: Is there a common link? World J Orthop 2017; 8(5): 412-423
URL	http://www.wjgnet.com/2218-5836/full/v8/i5/412.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i5.412

Full Article (PDF)	WJO-8-412.pdf
Full Article (Word)	WJO-8-412.doc
Manuscript File	31743-Review.docx
Answering Reviewers	31743-Answering reviewers.pdf
Audio Core Tip	31743-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31743-Conflict-of-interest statement.pdf
Copyright License Agreement	31743-Copyright assignment.pdf
Peer-review Report	31743-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31743-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31743-Scientific misconduct check.pdf
Scientific Editor Work List	31743-Scientific editor work list.pdf