BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/12/2017 1:42:23 PM | Browse: 1990 | Download: 3086
 |
Received |
|
2016-12-05 09:28 |
|
Peer-Review Started |
|
2016-12-06 15:13 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2017-01-16 18:13 |
|
Revised |
|
2017-01-28 04:58 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2017-02-20 16:00 |
|
Second Decision by Editor-in-Chief |
|
2017-02-23 11:29 |
|
Final Decision by Editorial Office Director |
|
2017-03-02 08:37 |
|
Articles in Press |
|
2017-03-02 08:37 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2017-05-09 15:05 |
|
Publish the Manuscript Online |
|
2017-05-12 13:42 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Dementia and osteoporosis in a geriatric population: Is there a common link?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Candice L Downey, Adam Young, Emily F Burton, Simon M Graham, Robert J Macfarlane, Eva-Maria Tsapakis and Eleftherios Tsiridis |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Simon M Graham, MBChB, MRCS, Department of Trauma and Orthopaedics, the Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, United Kingdom. simonmatthewgraham@doctors.org.uk |
| Key Words |
Osteoporosis; Fracture; Dementia; Thyroid disease; Alzheimer’s disease; Elderly; Vitamin D; Vitamin K; Calcium; Statins; Alcohol; Sex steroids |
| Core Tip |
A potential pathological link between osteo¬porosis and dementia has been explored in observational studies, but there exists a lack of large scale randomised controlled trials. We hypothesise that dementia and osteoporosis have common yet independent aetiologies. The most compelling evidence lies in the APOE4 allele, a well-established risk factor for Alzheimer’s disease. APOE4 is associated with fracture, independent of dementia and falling. The mechanism behind this is postulated to be reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele. This may be augmented by the nu¬tritional deficiencies associated with dementia, known to include vitamins K and D. |
| Publish Date |
2017-05-12 13:42 |
| Citation |
Downey CL, Young A, Burton EF, Graham SM, Macfarlane RJ, Tsapakis EM, Tsiridis E. Dementia and osteoporosis in a geriatric population: Is there a common link? World J Orthop 2017; 8(5): 412-423 |
| URL |
http://www.wjgnet.com/2218-5836/full/v8/i5/412.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v8.i5.412 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
