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5/12/2017 1:42:23 PM | Browse: 658 | Download: 563
Publication Name World Journal of Orthopedics
Manuscript ID 31743
Country of Manuscript Source United Kingdom
Received
2016-12-05 09:28
Peer-Review Started
2016-12-06 15:13
To Make the First Decision
2017-01-14 11:20
Return for Revision
2017-01-16 18:13
Revised
2017-01-28 04:58
Second Decision
2017-02-20 16:00
Accepted by Journal Editor-in-Chief
2017-02-23 11:29
Accepted by Company Editor-in-Chief
2017-03-02 08:37
Articles in Press
2017-03-02 08:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-09 15:05
Publish the Manuscript Online
2017-05-12 13:42
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Orthopedics
Manuscript Type Systematic Review
Article Title Dementia and osteoporosis in a geriatric population: Is there a common link?
Manuscript Source Invited Manuscript
All Author List Candice L Downey, Adam Young, Emily F Burton, Simon M Graham, Robert J Macfarlane, Eva-Maria Tsapakis and Eleftherios Tsiridis
Funding Agency and Grant Number
Corresponding author Simon M Graham, MBChB, MRCS, Department of Trauma and Orthopaedics, the Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, United Kingdom. simonmatthewgraham@doctors.org.uk
Keywords Osteoporosis; Fracture; Dementia; Thyroid disease; Alzheimer’s disease; Elderly; Vitamin D; Vitamin K; Calcium; Statins; Alcohol; Sex steroids
Core Tip A potential pathological link between osteo¬porosis and dementia has been explored in observational studies, but there exists a lack of large scale randomised controlled trials. We hypothesise that dementia and osteoporosis have common yet independent aetiologies. The most compelling evidence lies in the APOE4 allele, a well-established risk factor for Alzheimer’s disease. APOE4 is associated with fracture, independent of dementia and falling. The mechanism behind this is postulated to be reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele. This may be augmented by the nu¬tritional deficiencies associated with dementia, known to include vitamins K and D.
Publish Date 2017-05-12 13:42
Citation Downey CL, Young A, Burton EF, Graham SM, Macfarlane RJ, Tsapakis EM, Tsiridis E. Dementia and osteoporosis in a geriatric population: Is there a common link? World J Orthop 2017; 8(5): 412-423
Url http://www.wjgnet.com/2218-5836/full/v8/i5/412.htm
DOI http://dx.doi.org/10.5312/wjo.v8.i5.412
Full Article (PDF) WJO-8-412.pdf
Full Article (Word) WJO-8-412.doc
Manuscript File 31743-Review.docx
Answering Reviewers 31743-Answering reviewers.pdf
Audio Core Tip 31743-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31743-Conflict-of-interest statement.pdf
Copyright License Agreement 31743-Copyright assignment.pdf
Data Sharing Statement 31743-Data sharing statement.pdf
Scientific Research Process 31743-Scientific research process.pdf
Peer-review Report 31743-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 31743-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 31743-Scientific misconduct check.pdf
Scientific Editor Work List 31743-Scientific editor work list.pdf