4/20/2017 3:58:56 PM | Browse: 1633 | Download: 2997
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 31752 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2017. Published byBaishideng Publishing Group Inc.All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Clinical Trials Study | ||||||
| Article Title | Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Shu Dong, Zong-Ying Zhan, Hong-Yan Cao, Chao Wu, Yan-Qin Bian, Jian-Yuan Li, Gen-Hong Cheng, Ping Liu and Ming-Yu Sun | ||||||
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| Corresponding Author | Ming-yu Sun, MD, PhD, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New District, Shanghai 201203, China. mysun248@hotmail.com | ||||||
| Key Words | Urinary metabonomics; Nonalcoholic fatty liver disease; Steatohepatitis | ||||||
| Core Tip | To identify biomarkers that can distinguish between nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), urine and blood were obtained from patients with NAFLD and NASH, and healthy controls. Urinary metabonomics found differences in 31 metabolites between NAFLD and NASH, including nucleic acids and amino acids. Pathway analysis showed that pathways of energy metabolism, amino acid metabolism, and the pentose phosphate pathway, were closely associated with the pathological processes in NAFLD and NASH. These biomarkers could distinguish between NAFLD and NASH, and could help to determine the mechanism involved in the development of NASH from NAFLD. | ||||||
| Publish Date | 2017-04-20 15:58 | ||||||
| Citation | Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(15): 2771-2784 | ||||||
| URL | http://www.wjgnet.com/1007-9327/full/v23/i15/2771.htm | ||||||
| DOI | http://dx.doi.org/10.3748/wjg.v23.i15.2771 |
| Full Article (PDF) | WJG-23-2771.pdf |
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| Full Article (Word) | WJG-23-2771.doc |
| Manuscript File | 31752-Review.docx |
| Answering Reviewers | 31752-Answering reviewers.pdf |
| Audio Core Tip | 31752-Audio core tip.wav |
| Biostatistics Review Certificate | 31752-Biostatistics statement.pdf |
| Clinical Trial Registration Statement | 31752-Clinical trial registration statement.pdf |
| Conflict-of-Interest Disclosure Form | 31752-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 31752-Copyright assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 31752-Grant application form(s).pdf |
| Signed Informed Consent Form(s) or Document(s) | Informed_Consent_Statement_20161205155817.docx |
| Institutional Animal Care and Use Committee Approval Form or Document | 31752-Institutional animal care and use committee statement.docx |
| Institutional Review Board Approval Form or Document | 31752-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 31752-Language certificate.pdf |
| Peer-review Report | 31752-Peer-review(s).pdf |
| Scientific Misconduct Check | 31372-Scientific misconduct check.pdf |
| Scientific Editor Work List | 31752-Scientific editor work list.pdf |