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Articles Published Processes
4/14/2017 6:51:01 PM | Browse: 964 | Download: 1142
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Received |
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2016-12-07 10:31 |
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Peer-Review Started |
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2016-12-08 08:21 |
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To Make the First Decision |
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2016-12-29 09:10 |
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Return for Revision |
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2016-12-30 10:35 |
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Revised |
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2017-01-11 22:06 |
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Second Decision |
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2017-02-15 21:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-02-17 13:12 |
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Articles in Press |
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2017-02-17 13:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-22 20:48 |
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Typeset the Manuscript |
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2017-04-01 14:24 |
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Publish the Manuscript Online |
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2017-04-14 18:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Physiology |
| Manuscript Type |
Minireviews |
| Article Title |
New progress in roles of nitric oxide during hepatic ischemia reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Qi Zhang, Ning Ding, Yong-Fen Zeng, Yuan-Yuan Xiang, Mei-Wen Yang, Fen-Fang Hong and Shu-Long Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260504 |
| National Natural Science Foundation of China |
81660151 |
| National Natural Science Foundation of China |
81660751 |
| Science Foundation of Science Commission of Jiang Xi Province in China |
20161BBG70067 |
| School Teaching Reform foundation of Nanchang University |
NCUJGLX - 14-1-111 |
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| Corresponding Author |
Shu-long Yang, PhD, Professor, Department of Physiology, Basic Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, Jiangxi Province,
China. slyang@ncu.edu.cn |
| Key Words |
Liver; Hepatic ischemia reperfusion injury; Nitric oxide; Nitric oxide synthase |
| Core Tip |
The latest findings on the role of nitric oxide (NO) during hepatic ischemia reperfusion injury (HIRI) include: NO exerts a protective effect against HIRI by increasing NO bioavailability, downregulating p53 gene expression, decreasing inflammatory chemokines, reducing ROS by inhibiting the mitochondrial respiratory chain, activating sGC-GTP-cGMP signal pathway to reduce liver cell apoptosis, and regulating hepatic immune functions; eNOS protects against HIRI by increasing NO levels, several eNOS/NO signal pathways (such as Akt-eNOS/NO, AMPK-eNOS/NO and HIF-1α-eNOS/NO) participating in the anti-HIRI process; inhibiting over-expression of eNOS also protects against HIRI; and finally, the inhibition of iNOS prevented HIRI. |
| Publish Date |
2017-04-14 18:51 |
| Citation |
Zhang YQ, Ding N, Zeng YF, Xiang YY, Yang MW, Hong FF, Yang SL. New progress in roles of nitric oxide during hepatic ischemia reperfusion injury. World J Gastroenterol 2017; 23(14): 2505-2510 |
| URL |
http://www.wjgnet. com/1007-9327/full/v23/i14/2505.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i14.2505 |
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