Publication Name	World Journal of Gastroenterology
Manuscript ID	31809
Country	China

Received	2016-12-09 09:11
Peer-Review Started	2016-12-09 15:05
To Make the First Decision	2017-01-19 10:54
Return for Revision	2017-01-20 09:46
Revised	2017-01-23 12:21
Second Decision	2017-02-15 21:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-02-17 13:14
Articles in Press	2017-02-17 13:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-05-04 18:15
Typeset the Manuscript	2017-05-18 01:49
Publish the Manuscript Online	2017-05-20 12:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Basic Study
Article Title	Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Liu Yang, Zhong-Yang Shen, Rao-Rao Wang, Ming-Li Yin, Wei-Ping Zheng, Bin Wu, Tao Liu and Hong-Li Song
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270528 National Natural Science Foundation of China 81441022 National Natural Science Foundation of China 81670574 Natural Science Foundation of Tianjin, China 08JCYBJC08400 Natural Science Foundation of Tianjin, China 11JCZDJC27800 Natural Science Foundation of Tianjin, China 12JCZDJC25200 Technology Foundation of the Health Bureau in Tianjin, China 2011KY11
Corresponding Author	Hong-Li Song, MD, PhD, Professor of Medicine, Department of Organ Transplantation, Tianjin First Central Hospital and Tianjin Key Laboratory of Organ Transplantation, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. hlsong26@163.com
Key Words	Reduced-size liver transplantation; Bone marrow mesenchymal stem cells; Microcirculation; Heme oxygenase-1; Energy metabolism
Core Tip	Hepatic sinus is important in the liver microcirculation, which is the basis for transplanted liver regeneration. Transplanted liver grafts with disturbed microcirculation of the hepatic sinus may affect liver energy metabolism. We investigated the protective effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells (HO-1/BMMSCs) on rat reduced-size liver transplantation in terms of the microcirculation and hepatic energy metabolism. HO-1/BMMSCs promoted the equilibrium of ET-1/NO, repaired damaged hepatic sinusoidal endothelial cells, and lowered the portal vein pressure in rats following reduced-size liver transplantation, which improved the microcirculation of hepatic sinusoids and ATPase activity, and recover the energy metabolism of damaged hepatocytes.
Publish Date	2017-05-20 12:26
Citation	Yang L, Shen ZY, Wang RR, Yin ML, Zheng WP, Wu B, Liu T, Song HL. Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation. World J Gastroenterol 2017; 23(19): 3449-3467
URL	http://www.wjgnet.com/1007-9327/full/v23/i19/3449.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i19.3449

Full Article (PDF)	WJG-23-3449.pdf
Full Article (Word)	WJG-23-3449.doc
Manuscript File	31809-Review.doc
Answering Reviewers	31809-Answering reviewers.pdf
Audio Core Tip	31809-Audio core tip.mp3
Biostatistics Review Certificate	31809-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31809-Conflict-of-interest statement.pdf
Copyright License Agreement	31809-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31809-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	31809-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	31809-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31809-Language certificate.pdf
Scientific Misconduct Check	31809-Scientific misconduct check.pdf