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3/6/2017 1:27:00 PM | Browse: 869 | Download: 1817
Publication Name World Journal of Gastroenterology
Manuscript ID 31817
Country/Territory Germany
Received
2016-12-09 08:55
Peer-Review Started
2016-12-09 17:10
To Make the First Decision
2017-01-10 16:52
Return for Revision
2017-01-11 13:32
Revised
2017-01-24 22:55
Second Decision
2017-02-15 21:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-17 13:24
Articles in Press
2017-02-17 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-02-27 20:29
Publish the Manuscript Online
2017-03-06 13:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure
Manuscript Source Invited Manuscript
All Author List Karolin Thiel, Wilfried Klingert, Kathrin Klingert, Matthias H Morgalla, Martin U Schuhmann, Pamela Leckie, Yalda Sharifi, Nathan A Davies, Rajiv Jalan, Andreas Peter, Christian Grasshoff, Alfred Königsrainer, Martin Schenk and Christian Thiel
Funding Agency and Grant Number
Funding Agency Grant Number
TÜFF Programm 2341-0-0
Corresponding Author Christian Thiel, MD, Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Hoppe-Seyler Strasse 3, Tuebingen 72076, Germany. christian.thiel@med.uni-tuebingen.de
Key Words Acetaminophen intoxication; Acute liver failure; Portal blood flow; Thrombocytopenia; Animal model; Porcine model
Core Tip It still remains difficult to predict the outcome in patients with acute liver failure (ALF). Therefore we aimed to investigate the clinical course of portal blood flow (PBF) and changes in thrombocyte count in a porcine model of acetaminophen induced ALF. At manifestation of ALF, PBF increased maximally, followed by a rapidly decline until death due to multiple organ failure. In addition, thrombocytes values declined slowly at the onset of ALF. In the early ALF course, a second decline appeared 8 h after ALF escalating to a more severe thrombocytopenia after 16 h in ALF preceding fatality within few hours.
Publish Date 2017-03-06 13:24
Citation Thiel K, Klingert W, Klingert K, Morgalla MH, Schuhmann MU, Leckie P, Sharifi Y, Davies NA, Jalan R, Peter A, Grasshoff C, Königsrainer A, Schenk M, Thiel C. Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure. World J Gastroenterol 2017; 23(9): 1576-1585
URL http://www.wjgnet.com/1007-9327/full/v23/i9/1576.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i9.1576
Full Article (PDF) WJG-23-1576.pdf
Full Article (Word) WJG-23-1576.doc
Manuscript File 31817-Review.doc
Answering Reviewers 31817-Answering reviewers.pdf
Audio Core Tip 31817-Audio core tip.mp3
Biostatistics Review Certificate 31817-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31817-Conflict-of-interest statement.pdf
Copyright License Agreement 31817-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31817-Grant application form.pdf
Institutional Animal Care and Use Committee Approval Form or Document 31817-Insitutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 31817-Institutional review board statement.pdf
Peer-review Report 31817-Peer-review(s).pdf
Scientific Misconduct Check 31817-Scientific misconduct check.pdf
Scientific Editor Work List 31817-Scientific editor work list.pdf