Publication Name	World Journal of Gastroenterology
Manuscript ID	31817
Country	Germany

Received	2016-12-09 08:55
Peer-Review Started	2016-12-09 17:10
First Decision by Editorial Office Director
Return for Revision	2017-01-11 13:32
Revised	2017-01-24 22:55
Publication Fee Transferred
Second Decision by Editor	2017-02-15 21:12
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-02-17 13:24
Articles in Press	2017-02-17 13:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-27 20:29
Publish the Manuscript Online	2017-03-06 13:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Karolin Thiel, Wilfried Klingert, Kathrin Klingert, Matthias H Morgalla, Martin U Schuhmann, Pamela Leckie, Yalda Sharifi, Nathan A Davies, Rajiv Jalan, Andreas Peter, Christian Grasshoff, Alfred Königsrainer, Martin Schenk and Christian Thiel
Funding Agency and Grant Number	Funding Agency Grant Number TÜFF Programm 2341-0-0
Corresponding Author	Christian Thiel, MD, Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Hoppe-Seyler Strasse 3, Tuebingen 72076, Germany. christian.thiel@med.uni-tuebingen.de
Key Words	Acetaminophen intoxication; Acute liver failure; Portal blood flow; Thrombocytopenia; Animal model; Porcine model
Core Tip	It still remains difficult to predict the outcome in patients with acute liver failure (ALF). Therefore we aimed to investigate the clinical course of portal blood flow (PBF) and changes in thrombocyte count in a porcine model of acetaminophen induced ALF. At manifestation of ALF, PBF increased maximally, followed by a rapidly decline until death due to multiple organ failure. In addition, thrombocytes values declined slowly at the onset of ALF. In the early ALF course, a second decline appeared 8 h after ALF escalating to a more severe thrombocytopenia after 16 h in ALF preceding fatality within few hours.
Publish Date	2017-03-06 13:24
Citation	Thiel K, Klingert W, Klingert K, Morgalla MH, Schuhmann MU, Leckie P, Sharifi Y, Davies NA, Jalan R, Peter A, Grasshoff C, Königsrainer A, Schenk M, Thiel C. Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure. World J Gastroenterol 2017; 23(9): 1576-1585
URL	http://www.wjgnet.com/1007-9327/full/v23/i9/1576.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i9.1576

Full Article (PDF)	WJG-23-1576.pdf
Full Article (Word)	WJG-23-1576.doc
Manuscript File	31817-Review.doc
Answering Reviewers	31817-Answering reviewers.pdf
Audio Core Tip	31817-Audio core tip.mp3
Biostatistics Review Certificate	31817-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31817-Conflict-of-interest statement.pdf
Copyright License Agreement	31817-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	31817-Insitutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	31817-Institutional review board statement.pdf
Peer-review Report	31817-Peer-review(s).pdf
Scientific Misconduct Check	31817-Scientific misconduct check.pdf