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Articles Published Processes
3/28/2017 10:34:00 AM | Browse: 782 | Download: 1740
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Received |
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2016-12-11 14:50 |
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Peer-Review Started |
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2016-12-11 21:58 |
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To Make the First Decision |
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2017-01-10 16:52 |
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Return for Revision |
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2017-01-11 13:23 |
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Revised |
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2017-01-18 22:40 |
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Second Decision |
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2017-02-15 21:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-02-17 13:24 |
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Articles in Press |
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2017-02-17 13:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-04 12:57 |
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Typeset the Manuscript |
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2017-03-20 15:14 |
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Publish the Manuscript Online |
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2017-03-28 10:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Han, Ji-Hong Li, Guang Bai, Guo-Shun Shen, Jing Chen, Jia-Nan Liu, Shuo Wang and Xian-Jun Liu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xian-Jun Liu, PhD, Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenhe District, Shenyang 110866, Liaoning Province, China. synydoctor@163.com
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| Key Words |
Acanthopanax senticosus polysaccharide; Intestinal permeability; Tight junction; Nuclear factor-kappa B; Myosin light chain kinase |
| Core Tip |
Acanthopanax senticosus polysaccharides (ASPS) effectively protect against gastric tight junction (TJ) injury in sepsis. ASPS pretreatment significantly improved intestinal histological appearance and gut permeability, increased electron dense between adjoining cells, sustained the expression and redistribution of occludin and zonula occludens-1, suppressed the expression of nuclear factor-kappa B p65 (NF-κBp65) and phospho-inhibitor kappa B-alpha and myosin light chain kinase (MLCK), as well as phospho-myosin light-chain-2 in endotoxemia. These findings suggest that ASPS pretreatment may be associated with inhibition of the NF-κB/MLCK pathway and concomitant amelioration of gastric TJ dysfunction in the mouse model of endotoxemia.
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| Publish Date |
2017-03-28 10:34 |
| Citation |
Han J, Li JH, Bai G, Shen GS, Chen J, Liu JN, Wang S, Liu XJ. Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model. World J Gastroenterol 2017; 23(12): 2175-2184 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i12/2175.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i12.2175 |
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