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3/28/2017 10:34:00 AM | Browse: 219 | Download: 366
Publication Name World Journal of Gastroenterology
Manuscript ID 31819
Country of Manuscript Source China
Received
2016-12-11 14:50
Peer-Review Started
2016-12-11 21:58
To Make the First Decision
2017-01-10 16:52
Return for Revision
2017-01-11 13:23
Revised
2017-01-18 22:40
Second Decision
2017-02-15 21:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-17 13:24
Articles in Press
2017-02-17 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-03-04 12:57
Typeset the Manuscript
2017-03-20 15:14
Publish the Manuscript Online
2017-03-28 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Biology
Manuscript Type Basic Study
Article Title Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model
Manuscript Source Unsolicited Manuscript
All Author List Jie Han, Ji-Hong Li, Guang Bai, Guo-Shun Shen, Jing Chen, Jia-Nan Liu, Shuo Wang and Xian-Jun Liu
Funding Agency and Grant Number
Corresponding author Xian-Jun Liu, PhD, Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenhe District, Shenyang 110866, Liaoning Province, China. synydoctor@163.com
Keywords Acanthopanax senticosus polysaccharide; Intestinal permeability; Tight junction; Nuclear factor-kappa B; Myosin light chain kinase
Core Tip Acanthopanax senticosus polysaccharides (ASPS) effectively protect against gastric tight junction (TJ) injury in sepsis. ASPS pretreatment significantly improved intestinal histological appearance and gut permeability, increased electron dense between adjoining cells, sustained the expression and redistribution of occludin and zonula occludens-1, suppressed the expression of nuclear factor-kappa B p65 (NF-κBp65) and phospho-inhibitor kappa B-alpha and myosin light chain kinase (MLCK), as well as phospho-myosin light-chain-2 in endotoxemia. These findings suggest that ASPS pretreatment may be associated with inhibition of the NF-κB/MLCK pathway and concomitant amelioration of gastric TJ dysfunction in the mouse model of endotoxemia.
Publish Date 2017-03-28 10:34
Citation Han J, Li JH, Bai G, Shen GS, Chen J, Liu JN, Wang S, Liu XJ. Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model. World J Gastroenterol 2017; 23(12): 2175-2184
Url http://www.wjgnet.com/1007-9327/full/v23/i12/2175.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i12.2175
Full Article (PDF) WJG-23-2175.pdf
Full Article (Word) WJG-23-2175.doc
Manuscript File 31819-Review.doc
Answering Reviewers 31819-Answering reviewers.pdf
Audio Core Tip 31819-Audio core tip.mp3
Biostatistics Review Certificate 31819-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31819-Conflict-of-interest statement.pdf
Copyright License Agreement 31819-Copyright assignment.pdf
Data Sharing Statement 31819-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31819-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 31819-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 31819-Institutional review board statement.docx
Non-Native Speakers of English Editing Certificate 31819-Language certificate.pdf
Scientific Research Process 31819-Scientific research process.pdf
Peer-review Report 31819-Peer-review(s).pdf
Scientific Misconduct Check 31819-Scientific misconduct check.pdf
Scientific Editor Work List 31819-Scientific editor work list.pdf