BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/14/2017 6:51:01 PM | Browse: 945 | Download: 1427
Publication Name World Journal of Gastroenterology
Manuscript ID 31824
Country/Territory China
Received
2016-12-11 15:05
Peer-Review Started
2016-12-11 21:09
To Make the First Decision
2016-12-29 09:10
Return for Revision
2016-12-30 10:36
Revised
2017-01-26 23:23
Second Decision
2017-02-15 21:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-17 13:25
Articles in Press
2017-02-17 13:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-03-21 11:24
Typeset the Manuscript
2017-03-28 17:26
Publish the Manuscript Online
2017-04-14 18:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Jin-Liang Zhang, Min Liu, Qing Yang, Shi-Yong Lin, Hong-Bo Shan, Hui-Yun Wang and Guo-Liang Xu
Funding Agency and Grant Number
Corresponding Author Guo-Liang Xu, Professor, Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, East Building, Guangzhou 510060, Guangdong Province, China. xugl@sysucc.org.cn
Key Words Omeprazole; Chemoradiotherapy efficacy; Recurrence; Rectal cancer
Core Tip In in vitro and in vivo studies, proton pump inhibitors (PPIs) induce apoptosis of gastric cancer cells, B-cell tumors and hepatoblastoma cells and promote autophagy in melanoma cells and pancreatic cancer cells. PPIs also sensitize chemo-resistant tumors to cytotoxic drugs and improve the efficacy of T-cell-based cancer immunotherapy. However, whether PPIs affect chemoradiotherapy (CRT) efficacy, decrease tumor recurrence and improve survival in rectal cancer patients remains unclear. In the present study, when used as adjuvant drug in cancer treatment, omeprazole has a synergetic effect in improving CRT efficacy and decreasing recurrences in rectal cancer.
Publish Date 2017-04-14 18:51
Citation Zhang JL, Liu M, Yang Q, Lin SY, Shan HB, Wang HY, Xu GL. Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer. World J Gastroenterol 2017; 23(14): 2575-2584
URL http://www.wjgnet. com/1007-9327/full/v23/i14/2575.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i14.2575
Full Article (PDF) WJG-23-2575.pdf
Full Article (Word) WJG-23-2575.doc
Manuscript File 31824-Review.docx
Answering Reviewers 31824-Answering reviewers.pdf
Audio Core Tip 31824-Audio core tip.mp3
Biostatistics Review Certificate 31824-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31824-Conflict-of-interest statement.pdf
Copyright License Agreement 31824-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 31824-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31824-Language certificate.pdf
Peer-review Report 31824-Peer-review(s).pdf
Scientific Misconduct Check 31824-Scientific misconduct check.pdf
Scientific Editor Work List 31824-Scientific editor work list.pdf