Publication Name	World Journal of Gastroenterology
Manuscript ID	31824
Country	China

Received	2016-12-11 15:05
Peer-Review Started	2016-12-11 21:09
To Make the First Decision	2016-12-29 09:10
Return for Revision	2016-12-30 10:36
Revised	2017-01-26 23:23
Second Decision	2017-02-15 21:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-17 13:25
Articles in Press	2017-02-17 13:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-03-21 11:24
Typeset the Manuscript	2017-03-28 17:26
Publish the Manuscript Online	2017-04-14 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Liang Zhang, Min Liu, Qing Yang, Shi-Yong Lin, Hong-Bo Shan, Hui-Yun Wang and Guo-Liang Xu
Funding Agency and Grant Number
Corresponding Author	Guo-Liang Xu, Professor, Department of Endoscopy and Laser, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, East Building, Guangzhou 510060, Guangdong Province, China. xugl@sysucc.org.cn
Key Words	Omeprazole; Chemoradiotherapy efficacy; Recurrence; Rectal cancer
Core Tip	In in vitro and in vivo studies, proton pump inhibitors (PPIs) induce apoptosis of gastric cancer cells, B-cell tumors and hepatoblastoma cells and promote autophagy in melanoma cells and pancreatic cancer cells. PPIs also sensitize chemo-resistant tumors to cytotoxic drugs and improve the efficacy of T-cell-based cancer immunotherapy. However, whether PPIs affect chemoradiotherapy (CRT) efficacy, decrease tumor recurrence and improve survival in rectal cancer patients remains unclear. In the present study, when used as adjuvant drug in cancer treatment, omeprazole has a synergetic effect in improving CRT efficacy and decreasing recurrences in rectal cancer.
Publish Date	2017-04-14 18:51
Citation	Zhang JL, Liu M, Yang Q, Lin SY, Shan HB, Wang HY, Xu GL. Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer. World J Gastroenterol 2017; 23(14): 2575-2584
URL	http://www.wjgnet. com/1007-9327/full/v23/i14/2575.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i14.2575

Full Article (PDF)	WJG-23-2575.pdf
Full Article (Word)	WJG-23-2575.doc
Manuscript File	31824-Review.docx
Answering Reviewers	31824-Answering reviewers.pdf
Audio Core Tip	31824-Audio core tip.mp3
Biostatistics Review Certificate	31824-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31824-Conflict-of-interest statement.pdf
Copyright License Agreement	31824-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	31824-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31824-Language certificate.pdf
Peer-review Report	31824-Peer-review(s).pdf
Scientific Misconduct Check	31824-Scientific misconduct check.pdf
Scientific Editor Work List	31824-Scientific editor work list.pdf