Publication Name	World Journal of Gastroenterology
Manuscript ID	31878
Country	United States

Received	2016-12-13 10:34
Peer-Review Started	2016-12-14 20:59
To Make the First Decision	2016-12-29 08:54
Return for Revision	2017-01-04 19:36
Revised	2017-01-13 03:23
Second Decision	2017-03-09 17:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-15 13:36
Articles in Press	2017-03-15 13:36
Publication Fee Transferred	2017-04-15 01:39
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-10 13:29
Publish the Manuscript Online	2017-05-20 12:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line
Manuscript Source	Unsolicited Manuscript
All Author List	Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe and Lorraine M Sordillo
Funding Agency and Grant Number	Funding Agency Grant Number An endowment from the Matilda R. Wilson Fund in Detroit, Michigan
Corresponding Author	Dr. Lorraine M Sordillo, Professor, Meadow Brook Chair, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, East Lansing, MI 48824, United States. sordillo@msu.edu
Key Words	Colon cancer cell line; CRL.1790 cells; Inflammation; Mitochondria; Microbial stimulation; Interleukin-8; Autophagy
Core Tip	The normal human colon cell line, CRL.1970, can recapitulate oxidative stress-induced responses associated with inflammatory bowel disease following microbial challenge including enhanced production of reactive oxygen species (ROS), inflammatory cytokines, and enhanced mitochondrial autophagic responses. Scavenging mitochondrial ROS inhibited mitochondrial morphologic changes and autophagy suggesting that CRL.1790 cells can be used to study oxidative events associated with intestinal inflammatory disorders.
Publish Date	2017-05-20 12:26
Citation	Packiriswamy N, Coulson KF, Holcombe SJ, Sordillo LM. Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line. World J Gastroenterol 2017; 23(19): 3427-3439
URL	http://www.wjgnet.com/1007-9327/full/v23/i19/3427.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i19.3427

Full Article (PDF)	WJG-23-3427.pdf
Full Article (Word)	WJG-23-3427.doc
Manuscript File	31878-Review.docx
Answering Reviewers	31878-Answering reviewers.pdf
Audio Core Tip	31878-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31878-Conflict-of-interest statement.pdf
Copyright License Agreement	31878-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	31878-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20161212234531.docx
Peer-review Report	31878-Peer-review(s).pdf
Scientific Misconduct Check	31878-Scientific misconduct check.pdf
Scientific Editor Work List	31878-Scientific editor work list.pdf