Publication Name	World Journal of Gastroenterology
Manuscript ID	31891
Country	China

Received	2016-12-13 12:00
Peer-Review Started	2016-12-14 10:53
To Make the First Decision	2016-12-28 17:27
Return for Revision	2017-01-06 08:13
Revised	2017-01-18 20:58
Second Decision	2017-03-01 11:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-02 17:12
Articles in Press	2017-03-02 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-08 16:03
Publish the Manuscript Online	2017-03-19 18:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management
Manuscript Source	Invited Manuscript
All Author List	Ka-Shing Cheung and Wai K Leung
Funding Agency and Grant Number	Funding Agency Grant Number Li Shu Fan Medical Foundation Professorship (to Leung WK)
Corresponding Author	Wai K Leung, MD, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China. waikleung@hku.hk
Key Words	Warfarin; Endoscopy; Apixaban; Edoxaban; Gastrointestinal bleeding; Dabigatran; Rivaroxaban; Novel anticoagulants
Core Tip	Although effective in the prevention and treatment of thromboembolism, novel oral anticoa-gulants (NOACs) are still associated with bleeding complications including gastrointestinal bleeding (GIB). Physicians should exercise caution in the prescription of these drugs with careful review of the indications and appropriate dosage, as well as balancing the risks and benefits. Nonetheless, patients perceived to have an increased risk of GIB should not be precluded from taking NOACs, if they are also at a high risk of stroke. Instead, physicians should recognize the risk factors associated with NOAC-related GIB in order to undertake preventive measures to reduce the risk of GIB.
Publish Date	2017-03-19 18:45
Citation	Cheung KS, Leung WK. Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management. World J Gastroenterol 2017; 23(11): 1954-1963
URL	http://www.wjgnet.com/1007-9327/full/v23/i11/1954.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i11.1954

Full Article (PDF)	WJG-23-1954.pdf
Full Article (Word)	WJG-23-1954.doc
Manuscript File	31891-Review.docx
Answering Reviewers	31891-Answering reviewers.pdf
Audio Core Tip	31891-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	31891-Conflict-of-interest statement.pdf
Copyright License Agreement	31891-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20161213112504.docx
Peer-review Report	31891-Peer-review(s).pdf
Scientific Misconduct Check	31891-Scientific misconduct check.pdf
Scientific Editor Work List	31891-Scientific editor work list.pdf