Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	31900
Country	Japan

Received	2016-12-14 09:56
Peer-Review Started	2016-12-14 15:30
To Make the First Decision	2017-03-06 18:02
Return for Revision	2017-03-10 19:12
Revised	2017-03-20 00:53
Second Decision	2017-06-08 07:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-06-13 04:52
Articles in Press	2017-06-13 04:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-17 07:41
Publish the Manuscript Online	2017-08-10 23:54

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	S-1 induced hepatic steatosis in patients with pancreatic cancer: Retrospective analysis
Manuscript Source	Invited Manuscript
All Author List	Kunihiro Tsuji and Hisashi Doyama
Funding Agency and Grant Number
Corresponding Author	Dr. Kunihiro Tsuji, Department of Gastroenterology, Ishikawa Prefectural Central Hospital, 2-1 Kuratsukihigashi, Kanazawa, Ishikawa 920-8530, Japan. m92162g@ipch.jp
Key Words	S-1; Hepatic steatosis; Pancreatic cancer; Drug induced hepatitis; 5-fluorouracil
Core Tip	Drug induced hepatic steatosis is a rare form of liver injury. Although hepatic steatosis has been observed in some patients with pancreatic cancer who were administered S-1, the ability of 5-fluorouracil alone to induce hepatic steatosis has not been evaluated systematically. The purpose of our study was to determine whether S-1 induces hepatic steatosis in patients being treated for pancreatic cancer. After analyzing a total of 22 patients, we found that S-1 chemotherapy induced hepatic steatosis in some patients with pancreatic cancer within three months and the correlation between the development of hepatic steatosis and liver function was weak in these patients.
Publish Date	2017-08-10 23:54
Citation	Tsuji K, Doyama H. S-1 induced hepatic steatosis in patients with pancreatic cancer: Retrospective analysis. World J Gastrointest Oncol 2017; 9(8): 314-318
URL	http://www.wjgnet.com/1948-5204/full/v9/i8/314.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i8.314

Full Article (PDF)	WJGO-9-314.pdf
Full Article (Word)	WJGO-9-314.doc
Manuscript File	31900-Review.docx
Answering Reviewers	31900-Answering reviewers.pdf
Audio Core Tip	31900-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31900-Conflict-of-interest statement.pdf
Copyright License Agreement	31900-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	31900-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	31900-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31900-Language certificate.pdf
Peer-review Report	31900-Peer-review(s).pdf
Scientific Misconduct Check	31900-Scientific misconduct check.pdf
Scientific Editor Work List	31900-Scientific editor work list.pdf