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Articles Published Processes
7/28/2017 8:16:18 AM | Browse: 1100 | Download: 1718
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Received |
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2016-12-16 09:00 |
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Peer-Review Started |
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2016-12-17 20:27 |
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To Make the First Decision |
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2017-01-10 15:42 |
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Return for Revision |
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2017-01-16 17:54 |
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Revised |
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2017-02-21 03:33 |
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Second Decision |
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2017-04-27 17:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-04 18:20 |
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Articles in Press |
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2017-05-04 18:20 |
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Publication Fee Transferred |
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2017-06-08 10:28 |
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Edit the Manuscript by Language Editor |
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2017-07-04 00:24 |
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Typeset the Manuscript |
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2017-07-19 02:37 |
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Publish the Manuscript Online |
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2017-07-28 08:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fernando Díaz-Fontenla, Marta Castillo-Pradillo, Arantxa Díaz-Gómez, Luis Ibañez-Samaniego, Pilar Gancedo, Juan Adan Guzmán-de-Villoria, Pilar Fernández-García, Rafael Bañares-Cañizares and Rita García-Martínez |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rita García-Martínez, Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Calle del Doctor Esquerdo 46, Madrid 28007, Spain. rgarciamartinez3@salud.madrid.org |
| Key Words |
Hepatic encephalopathy; Hypothyroidism; Cognitive impairment; Cirrhosis; Portosystemic shunt; Magnetic resonance spectroscopy |
| Core Tip |
Hepatic encephalopathy (HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE requires the search of hidden precipitating events and alternative diagnosis. We describe a patient with refractory HE who presented with large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment, hyperammonaemia, electroencephalograph alterations, impaired neuropsychological performance and magnetic resonance imaging and spectroscopy disturbances suggestive of HE paralleled the course of hypothyroidism and improved after thyroid hormone replacement. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. |
| Publish Date |
2017-07-28 08:16 |
| Citation |
Díaz-Fontenla F, Castillo-Pradillo M, Díaz-Gómez A, Ibáñez-Samaniego L, Gancedo P, Guzmán-de-Villoria JA, Fernández-García P, Bañares-Cañizares R, García-Martínez R. Refractory hepatic encephalopathy in a patient with hypothyroidism: another element in ammonia metabolism. World J Gastroenterol 2017; 23(28): 5246-5252 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i28/5246.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i28.5246 |
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