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7/28/2017 8:16:18 AM | Browse: 380 | Download: 356
Publication Name World Journal of Gastroenterology
Manuscript ID 31931
Country/Territory Spain
2016-12-16 09:00
Peer-Review Started
2016-12-17 20:27
To Make the First Decision
2017-01-10 15:42
Return for Revision
2017-01-16 17:54
2017-02-21 03:33
Second Decision
2017-04-27 17:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-04 18:20
Articles in Press
2017-05-04 18:20
Publication Fee Transferred
2017-06-08 10:28
Edit the Manuscript by Language Editor
2017-07-04 00:24
Typeset the Manuscript
2017-07-19 02:37
Publish the Manuscript Online
2017-07-28 08:16
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism
Manuscript Source Unsolicited Manuscript
All Author List Fernando Díaz-Fontenla, Marta Castillo-Pradillo, Arantxa Díaz-Gómez, Luis Ibañez-Samaniego, Pilar Gancedo, Juan Adan Guzmán-de-Villoria, Pilar Fernández-García, Rafael Bañares-Cañizares and Rita García-Martínez
Funding Agency and Grant Number
Corresponding author Rita García-Martínez, Unidad de Hepatología, Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Calle del Doctor Esquerdo 46, Madrid 28007, Spain. rgarciamartinez3@salud.madrid.org
Keywords Hepatic encephalopathy; Hypothyroidism; Cognitive impairment; Cirrhosis; Portosystemic shunt; Magnetic resonance spectroscopy
Core Tip Hepatic encephalopathy (HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE requires the search of hidden precipitating events and alternative diagnosis. We describe a patient with refractory HE who pre­sented with large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment, hyperammonaemia, electroencephalograph alterations, impaired neuropsychological performance and magnetic resonance imaging and spectroscopy disturbances suggestive of HE paralleled the course of hypothyroidism and improved after thyroid hormone replacement. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity.
Publish Date 2017-07-28 08:16
Citation Díaz-Fontenla F, Castillo-Pradillo M, Díaz-Gómez A, Ibáñez-Samaniego L, Gancedo P, Guzmán-de-Villoria JA, Fernández-García P, Bañares-Cañizares R, García-Martínez R. Refractory hepatic encephalopathy in a patient with hypothyroidism: another element in ammonia metabolism. World J Gastroenterol 2017; 23(28): 5246-5252
Url http://www.wjgnet.com/1007-9327/full/v23/i28/5246.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i28.5246
Full Article (PDF) WJG-23-5246.pdf
Full Article (Word) WJG-23-5246.doc
Manuscript File 31931-Review.doc
Answering Reviewers 31931-Answering reviewers.pdf
Audio Core Tip 31931-Audio core tip.wma
Conflict-of-Interest Disclosure Form 31931-Conflict-of-interest statement.pdf
Copyright License Agreement 31931-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 31931-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 31931-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31931-Language certificate.pdf
Peer-review Report 31931-Peer-review(s).pdf
Scientific Misconduct Check 31931-Scientific misconduct check.pdf
Scientific Editor Work List 31931-Scientific editor work list.pdf