Publication Name	World Journal of Gastroenterology
Manuscript ID	31942
Country	Italy

Received	2016-12-19 10:27
Peer-Review Started	2016-12-19 17:02
To Make the First Decision	2017-02-09 13:49
Return for Revision	2017-02-10 10:13
Revised	2017-04-07 20:46
Second Decision	2017-05-27 01:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-06-01 08:49
Articles in Press	2017-06-01 08:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-22 02:38
Publish the Manuscript Online	2017-07-07 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Nutrition & Dietetics
Manuscript Type	Observational Study
Article Title	Functional lipidomics in patients on home parenteral nutrition: Effect of lipid emulsions
Manuscript Source	Invited Manuscript
All Author List	Loris Pironi, Mariacristina Guidetti, Ornella Verrastro, Claudia Iacona, Federica Agostini, Caterina Pazzeschi, Anna Simona Sasdelli, Michele Melchiorre and Carla Ferreri
Funding Agency and Grant Number
Corresponding Author	Loris Pironi, MD, PhD, Professor, Director, Chronic Intestinal Failure Center, Digestive Disease Department, St Orsola-Malpighi Hospital, Department of medical and Surgical Science, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. loris.pironi@unibo.it
Key Words	Chronic intestinal failure; Home parenteral nutrition; Intravenous lipid emulsion; Cell membrane fatty acid profile; Cell membrane lipidome; Functional lipidomics
Core Tip	Fatty acid-based “functional lipidomics” investigates the structural and functional roles played by lipids and their in vivo changes, and provides the rationalisation of these changes in connection with their biological significance. In this study, the effects of two intravenous lipid emulsions with different fatty acids profiles on the red blood cell membrane lipidome in patients on long-term home parenteral nutrition for chronic intestinal failure were investigated. The results were analysed in terms of functional lipidomics. The membrane lipidome was significantly modified by the fatty acid profile of the intravenous lipid emulsions. Functional lipidomics indicated that both the lipid emulsion fatty acid profile and the glucose amount of the parenteral nutrition admixture play a role in regulating the activity of the enzymes of the fatty acid metabolism pathways.
Publish Date	2017-07-07 11:41
Citation	Pironi L, Guidetti M, Verrastro O, Iacona C, Agostini F, Pazzeschi C, Sasdelli AS, Melchiorre M, Ferreri C. Functional lipidomics in patients on home parenteral nutrition: Effect of lipid emulsions. World J Gastroenterol 2017; 23(25): 4604-4614
URL	http://www.wjgnet.com/1007-9327/full/v23/i25/4604.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i25.4604

Full Article (PDF)	WJG-23-4604.pdf
Full Article (Word)	WJG-23-4604.doc
Manuscript File	31942-Review.docx
Answering Reviewers	31942-Answering reviewers.pdf
Audio Core Tip	31942-Audio core tip.mp3
Biostatistics Review Certificate	31942-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31942-Conflict-of-interest statement.pdf
Copyright License Agreement	31942-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	31942-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	31942-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31942-Language certificate.pdf
Peer-review Report	31942-Peer-review(s).pdf
Scientific Misconduct Check	31942-Scientific misconduct check.pdf
Scientific Editor Work List	31942-Scientific editor work list.pdf