Publication Name	World Journal of Clinical Cases
Manuscript ID	31943
Country	Italy

Received	2016-12-16 08:25
Peer-Review Started	2016-12-19 10:04
To Make the First Decision	2017-03-27 11:54
Return for Revision	2017-03-28 17:01
Revised	2017-04-06 19:45
Second Decision	2017-06-02 00:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-13 04:59
Articles in Press	2017-06-13 04:59
Publication Fee Transferred	2017-08-08 10:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-10 01:16
Publish the Manuscript Online	2017-11-17 09:05

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Natural killer cells activity in a metastatic colorectal cancer patient with complete and long lasting response to therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Alessandro Ottaiano, Maria Napolitano, Monica Capozzi, Salvatore Tafuto, Antonio Avallone and Stefania Scala
Funding Agency and Grant Number
Corresponding Author	Dr. Alessandro Ottaiano, Department of Abdominal Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” – I.R.C.C.S., via M. Semmola, 80131 Naples, Italy. ale.otto@libero.it
Key Words	Colorectal cancer; Panitumumab; Natural killers; Regulatory cells; Chemotherapy
Core Tip	The case presented here shows a patients with metastatic colorectal cancer (mCRC) and long-lasting responses to different treatments including chemotherapies and targeted therapies; in particular, the patient had a long-lasting complete response to panitumumab. Additionally, he presented a high proportion of circulating natural killer (NK) cells displaying high cytotoxic activity against tumor cells in vitro. Interestingly, we previously reported that patients affected by mCRC with high NK-cell cytotoxicity showed a significantly higher response rate and a longer progression-free survival compared with patients with low NK-cell cytotoxicity. Study on the role of NK in patients with mCRC should be improved.
Publish Date	2017-11-17 09:05
Citation	Ottaiano A, Napolitano M, Capozzi M, Tafuto S, Avallone A, Scala S. Natural killer cells activity in a metastatic colorectal cancer patient with complete and long lasting response to therapy. World J Clin Cases 2017; In press
URL	http://www.wjgnet.com/2307-8960/full/v5/i11/390.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i11.390

Full Article (PDF)	WJCC-5-390.pdf
Full Article (Word)	WJCC-5-390.doc
Manuscript File	31943-Review.doc
Answering Reviewers	31943-Answering reviewers.pdf
Audio Core Tip	31943-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31943-Conflict-of-interest statement.pdf
Copyright License Agreement	31943-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	31943-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	31943-Institutional review board statement.pdf
Peer-review Report	31943-Peer-review(s).pdf
Scientific Misconduct Check	31943-Scientific misconduct check.pdf
Scientific Editor Work List	31943-Scientific editor work list.pdf