Publication Name	World Journal of Gastroenterology
Manuscript ID	31948
Country	Italy

Received	2016-12-18 10:43
Peer-Review Started	2016-12-19 17:12
To Make the First Decision	2017-01-19 13:32
Return for Revision	2017-02-17 17:09
Revised	2017-02-21 20:32
Second Decision	2017-03-17 18:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-20 15:18
Articles in Press	2017-03-20 15:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-30 09:30
Publish the Manuscript Online	2017-04-14 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy?
Manuscript Source	Invited Manuscript
All Author List	Enzo Ierardi, Floriana Giorgio, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Antonio Pisani and Alfredo Di Leo
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy. e.ierardi@virgilio.it
Key Words	Helicobacter pylori; Antibiotic resistance; Noninvasive molecular test; Tailored therapy; Stool
Core Tip	The main problem of Helicobacter pylori (H. pylori) infection management is linked to antibiotic resistances. They are due to point mutations in bacterial DNA. Polymerase chain reaction-based, culture-free techniques on gastric biopsy samples are accurate in finding minimal traces of genotypic resistant and hetero-resistant strains. The need for endoscopic procedure is the most important limit to their spread. Therefore, the further step has been the detection of point mutations in bacterial DNA fecal samples. There is increasing evidence of potential availability of noninvasive investigations able to detect H. pylori resistances to antibiotics, which may lead to tailored first-line therapies.
Publish Date	2017-04-14 18:51
Citation	Ierardi E, Giorgio F, Iannone A, Losurdo G, Principi M, Barone M, Pisani A, Di Leo A. Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy? World J Gastroenterol 2017; 23(14): 2453-2458
URL	http://www.wjgnet.com/1007-9327/full/v23/i14/2453.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i14.2453

Full Article (PDF)	WJG-23-2453.pdf
Full Article (Word)	WJG-23-2453.doc
Manuscript File	31948-Review.doc
Answering Reviewers	31948-Answering reviewers.pdf
Audio Core Tip	31948-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31948-Conflict-of-interest statement.pdf
Copyright License Agreement	31948-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31948-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	31948-Language certificate.pdf
Peer-review Report	31948-Peer-review(s).pdf
Scientific Misconduct Check	31948-Scientific misconduct check.pdf
Scientific Editor Work List	31948-Scientific editor work list.pdf