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6/6/2017 12:54:56 AM | Browse: 159 | Download: 71
Publication Name World Journal of Hepatology
Manuscript ID 31953
Country of Manuscript Source United States
Received
2016-12-18 10:54
Peer-Review Started
2016-12-19 15:23
To Make the First Decision
2017-01-14 10:45
Return for Revision
2017-01-28 12:59
Revised
2017-01-31 02:01
Second Decision
2017-04-10 18:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-20 08:42
Articles in Press
2017-04-20 08:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-23 10:09
Publish the Manuscript Online
2017-06-06 00:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Review
Article Title Non-alcoholic fatty liver disease: An expanded review
Manuscript Source Invited Manuscript
All Author List Mark Benedict and Xuchen Zhang
Funding Agency and Grant Number
Correspondence To Xuchen Zhang, MD, PhD, Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LH 108, PO Box 208023, New Haven, CT 06520, United States. xuchen.zhang@yale.edu
Keywords Non-alcoholic fatty liver disease; Metabolic syndrome; Steatohepatitis; Hepatocellular carcinoma; Steatosis
Core Tip Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. NAFLD patients are at increased risk of liver-related as well as cardiovascular mortality, and NAFLD is rapidly becoming the leading indication for liver transplantation. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology. However, the exact pathogenic mechanism of NAFLD still remains unclear, and there is no effective treatment yet so far. In this review we summarized the current knowledge of NAFLD epidemiology, risk factors, diagnosis, pathogenesis, pathologic changes, natural history, and treatment.
Publish Date 2017-06-06 00:54
Citation Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol 2017; 9(16): 715-732
Url http://www.wjgnet.com/1948-5182/full/v9/i16/715.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i16.715
Full Article (PDF) WJH-9-715.pdf
Full Article (Word) WJH-9-715.doc
Revised Manuscript 31953-Review.docx
Peer-review Report 31953-Peer-review(s).pdf
Answering Reviewers 31953-Answering reviewers.pdf
Scientific Misconduct Check 31953-Scientific misconduct check.pdf
Scientific Editor Work List 31953-Scientific editor work list.pdf
Audio Core Tip 31953-Audio core tip.wav
Conflict-of-Interest Disclosure Form 31953-Conflict-of-interest statement.pdf
Copyright License Agreement 31953-Copyright assignment.pdf