Publication Name	World Journal of Hepatology
Manuscript ID	31953
Country	United States

Received	2016-12-18 10:54
Peer-Review Started	2016-12-19 15:23
To Make the First Decision	2017-01-14 10:45
Return for Revision	2017-01-28 12:59
Revised	2017-01-31 02:01
Second Decision	2017-04-10 18:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-04-20 08:42
Articles in Press	2017-04-20 08:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-23 10:09
Publish the Manuscript Online	2017-06-06 00:54

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Non-alcoholic fatty liver disease: An expanded review
Manuscript Source	Invited Manuscript
All Author List	Mark Benedict and Xuchen Zhang
Funding Agency and Grant Number
Corresponding Author	Xuchen Zhang, MD, PhD, Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LH 108, PO Box 208023, New Haven, CT 06520, United States. xuchen.zhang@yale.edu
Key Words	Non-alcoholic fatty liver disease; Metabolic syndrome; Steatohepatitis; Hepatocellular carcinoma; Steatosis
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. NAFLD patients are at increased risk of liver-related as well as cardiovascular mortality, and NAFLD is rapidly becoming the leading indication for liver transplantation. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology. However, the exact pathogenic mechanism of NAFLD still remains unclear, and there is no effective treatment yet so far. In this review we summarized the current knowledge of NAFLD epidemiology, risk factors, diagnosis, pathogenesis, pathologic changes, natural history, and treatment.
Publish Date	2017-06-06 00:54
Citation	Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol 2017; 9(16): 715-732
URL	http://www.wjgnet.com/1948-5182/full/v9/i16/715.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i16.715

Full Article (PDF)	WJH-9-715.pdf
Full Article (Word)	WJH-9-715.doc
Manuscript File	31953-Review.docx
Answering Reviewers	31953-Answering reviewers.pdf
Audio Core Tip	31953-Audio core tip.wav
Conflict-of-Interest Disclosure Form	31953-Conflict-of-interest statement.pdf
Copyright License Agreement	31953-Copyright assignment.pdf
Peer-review Report	31953-Peer-review(s).pdf
Scientific Misconduct Check	31953-Scientific misconduct check.pdf
Scientific Editor Work List	31953-Scientific editor work list.pdf