Publication Name	World Journal of Diabetes
Manuscript ID	31972
Country	Italy

Received	2016-12-21 09:48
Peer-Review Started	2016-12-26 12:05
To Make the First Decision	2017-03-27 11:54
Return for Revision	2017-03-28 17:05
Revised	2017-04-11 22:34
Second Decision	2017-05-02 11:10
Accepted by Journal Editor-in-Chief	2017-05-02 16:50
Accepted by Company Editor-in-Chief	2017-05-15 04:05
Articles in Press	2017-05-15 04:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-26 01:15
Publish the Manuscript Online	2017-07-03 04:05

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	PTPN22 and islet-specific autoimmunity: What have the mouse models taught us?
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Galvani and Georgia Fousteri
Funding Agency and Grant Number
Corresponding Author	Georgia Fousteri, MSc, PhD, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy. fousteri.georgia@hsr.it
Key Words	Protein tyrosin phosphatase non-receptor 22; Type 1 diabetes; Genetic susceptibility; Mouse model; Autoimmunity; Islet-specific autoimmunity
Core Tip	Protein tyrosin phosphatase non-receptor 22 (PTPN22) is the strongest non-HLA gene associated with type 1 diabetes (T1D) and many other autoimmune diseases. Several studies using mouse models have generated controversial results on how PTPN22 predisposes to T1D. In our manuscript we summarize these results and try to explain the discrepancies. Our analysis reveals that PTPN22 assumes different roles in innate and adaptive immunity and its effect is strongly dependent on other genetic variables. Hence, additional studies are required to better understand the mechanism by which PTPN22 predisposes to T1D and to exploit it as a potential therapeutic target in T1D and other autoimmune diseases.
Publish Date	2017-07-03 04:05
Citation	Galvani G, Fousteri G. PTPN22 and islet-specific autoimmunity: What have the mouse models taught us? World J Diabetes 2017; 8(7): 330-336
URL	http://www.wjgnet.com/1948-9358/full/v8/i7/330.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i7.330

Full Article (PDF)	WJD-8-330.pdf
Full Article (Word)	WJD-8-330.doc
Manuscript File	31972-Review.docx
Answering Reviewers	31972-Answering reviewers.pdf
Audio Core Tip	31972-Audio core tip.wav
Conflict-of-Interest Disclosure Form	31972-Conflict-of-interest statement.pdf
Copyright License Agreement	31972-Copyright assignment.pdf
Peer-review Report	31972-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31972-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31972-Scientific misconduct check.pdf
Scientific Editor Work List	31972-Scientific editor work list.pdf