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Articles Published Processes
5/12/2017 10:16:48 PM | Browse: 720 | Download: 1513
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Received |
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2016-12-21 09:43 |
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Peer-Review Started |
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2016-12-25 11:52 |
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To Make the First Decision |
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2017-01-14 11:28 |
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Return for Revision |
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2017-01-16 19:29 |
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Revised |
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2017-01-30 19:20 |
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Second Decision |
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2017-02-20 16:02 |
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Accepted by Journal Editor-in-Chief |
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2017-02-21 20:35 |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 08:40 |
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Articles in Press |
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2017-03-02 08:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-06 20:04 |
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Publish the Manuscript Online |
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2017-05-12 22:16 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Structural and nucleic acid binding properties of hepatitis delta virus small antigen
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Carolina Alves, Hong Cheng, João Paulo Tavanez, Ana Casaca, Severin Gudima, Heinrich Roder and Celso Cunha |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação para a Ciência e Tecnologia |
FCT, to GHTM - UID/Multi/04413/2013 |
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FCT PhD grants |
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FCT post-doctoral fellowship SFRH/BPD/87494/2012 |
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| Corresponding Author |
Celso Cunha, Associate Professor, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Portugal. ccunha@ihmt.unl.pt |
| Key Words |
Hepatitis delta virus; Delta antigen; Nuclear magnetic resonance; Circular dichroism; Intrinsically disordered protein |
| Core Tip |
The characterization of a truncated form of S-HDAg lacking amino acids 1-60, ?60HDAg is reported. Structure of ?60HDAg was assessed by circular dichroism and nuclear magnetic resonance and its nucleic acid binding properties were investigated using gel retardation assays. This study demonstrates for the first time that ?60HDAg is intrinsically disordered and a monomer. Furthermore, ?60HDAg can bind a wide variety of nucleic acids without apparent specificity. |
| Publish Date |
2017-05-12 22:16 |
| Citation |
Alves C, Cheng H, Tavanez JP, Casaca A, Gudima S, Roder H, Cunha C. Structural and nucleic acid binding properties of hepatitis delta virus small antigen. World J Virol 2017; 6(2): 26-35 |
| URL |
http://www.wjgnet.com/2220-3249/full/v6/i2/26.htm |
| DOI |
http://dx.doi.org/10.5501/wjv.v6.i2.26 |
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