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Articles Published Processes
4/6/2017 6:30:00 PM | Browse: 871 | Download: 1873
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Received |
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2016-12-23 09:45 |
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Peer-Review Started |
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2016-12-23 15:07 |
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To Make the First Decision |
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2017-01-10 16:15 |
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Return for Revision |
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2017-01-14 12:01 |
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Revised |
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2017-01-26 20:07 |
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Second Decision |
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2017-02-15 19:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-02-17 09:16 |
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Articles in Press |
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2017-02-17 09:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-01 06:57 |
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Typeset the Manuscript |
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2017-03-22 16:23 |
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Publish the Manuscript Online |
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2017-04-06 18:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Wang, Ruo-Wu Shen, Bing Han, Zhen Li, Le Xiong, Feng-Yu Zhang, Bei-Bei Cong and Bei Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
2014ZRB01466 |
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| Corresponding Author |
Dr. Bei Zhang, Department of Immunology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, Shandong Province, China. zhangbei124@aliyun.com |
| Key Words |
Notch; Peripheral blood mononuclear cells; Concanavalin A; Transforming growth factor-β; Liver fibrosis |
| Core Tip |
Notch and transforming growth factor (TGF)-β activation plays an important role in liver fibrosis induced by concanavalin A. It has been shown that TGF-β facilitates liver fibrosis. However, the mechanism of action of Notch in liver fibrosis is not fully understood. In this study, we found that excessive activation of TGF-β regulated Notch in liver fibrosis in rats, and that inhibition of TGF-β signaling blocked Notch signaling and vice versa. This may be a complementary mechanism of liver fibrosis, which provides a potential immunotherapeutic strategy. |
| Publish Date |
2017-04-06 18:30 |
| Citation |
Wang Y, Shen RW, Han B, Li Z, Xiong L, Zhang FY, Cong BB, Zhang B. Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats. World J Gastroenterol 2017; 23(13): 2330-2336 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i13/2330.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i13.2330 |
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