Publication Name	World Journal of Gastroenterology
Manuscript ID	32086
Country	Italy

Received	2016-12-24 17:05
Peer-Review Started	2016-12-28 17:55
To Make the First Decision	2017-02-09 15:04
Return for Revision	2017-02-14 10:20
Revised	2017-02-28 17:52
Second Decision	2017-04-11 15:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-13 11:04
Articles in Press	2017-04-13 11:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-24 18:03
Publish the Manuscript Online	2017-05-20 12:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Flavia A Cimini, Ilaria Barchetta, Simone Carotti, Laura Bertoccini, Marco G Baroni, Umberto Vespasiani-Gentilucci, Maria Gisella Cavallo and Sergio Morini
Funding Agency and Grant Number
Corresponding Author	Sergio Morini, MD, Professor, Laboratory of Microscopic and Ultrastructural Anatomy (CIR), Faculty of Medicine, University Campus Bio-Medico, Via Alvaro Del Portillo, 21, 00128 Rome, Italy. s.morini@unicampus.it
Key Words	Adipose tissue dysfunction; Vitamin D; Non-alcoholic fatty liver disease; Steatosis; Non-alcoholic steatohepatitis; Obesity; Adipokines
Core Tip	Obesity-associated chronic low-grade in­flammation plays a pivotal role in the development of non-alcoholic fatty liver disease (NAFLD). Vitamin D deficiency is associated with both obesity and NAFLD, and its anti-inflammatory and immune-modulatory properties provided plausible mechanisms by which hypovitaminosis D may link adipose tissue dysfunction and NAFLD. Animal studies showed beneficial effect of vitamin D supplementation on systemic inflammation and NAFLD, but these data are not confirmed by the results of clinical trials so far conducted in humans.
Publish Date	2017-05-20 12:26
Citation	Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-Gentilucci U, Cavallo MG, Morini S. relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease. World J Gastroenterol 2017; 23(19): 3407-3417
URL	http://www.wjgnet.com/1007-9327/full/v23/i19/3407.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i19.3407

Full Article (PDF)	WJG-23-3407.pdf
Full Article (Word)	WJG-23-3407.doc
Manuscript File	32086-Review.docx
Answering Reviewers	32086-Answering reviewers.pdf
Audio Core Tip	32086-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32086-Conflict-of-interest statement.pdf
Copyright License Agreement	32086-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	32086-Language Certificate.pdf
Peer-review Report	32086-Peer-review(s).pdf
Scientific Misconduct Check	32086-Scientific misconduct check.pdf
Scientific Editor Work List	32086-Scientific editor work list.pdf