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Articles Published Processes
9/7/2017 8:51:55 AM | Browse: 1008 | Download: 1760
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Received |
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2016-12-25 11:12 |
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Peer-Review Started |
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2016-12-29 18:20 |
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To Make the First Decision |
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2017-03-16 13:43 |
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Return for Revision |
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2017-03-18 18:58 |
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Revised |
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2017-04-13 22:56 |
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Second Decision |
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2017-07-06 07:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-24 07:58 |
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Articles in Press |
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2017-07-24 07:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-08-04 20:56 |
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Typeset the Manuscript |
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2017-08-25 03:59 |
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Publish the Manuscript Online |
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2017-09-07 08:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Ming Chen, Wei-Dong Chen, Xue-Mei Jiang, Xue-Feng Jia, Hong-Mei Wang, Qiu-Jie Zhang, Yong-Qian Shu and Hai-Bo Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Provincial Natural Science Foundation, China |
ZR2016HQ08 |
| Shandong Province medical science and technology development projects |
2016WS0151 |
| Jining Municipal Project on Science and Technology Development |
2013jnwk58 |
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| Corresponding Author |
Hai-Bo Zhao, Department of Oncology, Jining NO.1 People’s Hospital, NO.6, Jiankang Road, Jining 272011, Shandong Province, China. zhbys@sina.com |
| Key Words |
Long noncoding RNA; HOX transcript antisense intergenic RNA; Gastric cancer; Migration and invasion; E-cadherin |
| Core Tip |
In this study, we found that HOX transcript antisense intergenic RNA (HOTAIR) expression was up-regulated in gastric cancer (GC) tissues. High expression of HOTAIR was associated with clinicopathological characteristics and poor prognosis in GC patients. Additional experiments revealed that HOTAIR knockdown significantly inhibited the invasion and migration of GC cells. We also tested whether HOTAIR recruited EZH2 to promote tumor cell migration and invasion by repressing E-cadherin in GC. The findings from our study will help clarify the role of HOTAIR in GC progression and its potential as a therapeutic target. |
| Publish Date |
2017-09-07 08:51 |
| Citation |
Chen WM, Chen WD, Jiang XM, Jia XF, Wang HM, Zhang QJ, Shu YQ, Zhao HB. HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer. World J Gastroenterol 2017; 23(33): 6100-6110 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i33/6100.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i33.6100 |
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