Publication Name	World Journal of Diabetes
Manuscript ID	32099
Country	Greece

Received	2016-12-25 11:20
Peer-Review Started	2016-12-28 14:03
To Make the First Decision	2017-02-17 09:12
Return for Revision	2017-02-17 14:43
Revised	2017-02-27 02:47
Second Decision	2017-03-13 10:48
Accepted by Journal Editor-in-Chief	2017-03-14 16:37
Accepted by Company Editor-in-Chief	2017-03-24 10:46
Articles in Press	2017-03-24 10:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-26 01:14
Publish the Manuscript Online	2017-07-03 04:05

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	PCSK9 and carbohydrate metabolism: A double-edged sword
Manuscript Source	Invited Manuscript
All Author List	Theodosios D Filippatos, Sebastian Filippas-Ntekouan, Eleni Pappa, Thalia Panagiotopoulou, Vasilios Tsimihodimos and Moses S Elisaf
Funding Agency and Grant Number
Corresponding Author	Moses S Elisaf, Professor, Department of Internal Medicine, School of Medicine, University of Ioannina, Staurou Niarchou Avenue, 45110 Ioannina, Greece. melisaf54@gmail.com
Key Words	Proprotein convertase subtilisin/kexin type 9; Diabetes; Carbohydrate metabolism; Low-density lipoprotein; Proprotein convertase subtilisin/kexin type 9 inhibitors
Core Tip	Proprotein convertase subtilisin/kexin type 9 (PCSK9) may play a beneficial role in carbohydrate metabolism because it can decrease low-density lipoprotein receptor and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion. In contrast, clinical data have suggested a detrimental association of PCSK9 with glucose metabolism. These conflicting mechanisms may lead to a neutral effect on carbohydrate variables and explain the results of short-term clinical trials with PCSK9 inhibitors, which have not shown an increased diabetes risk.
Publish Date	2017-07-03 04:05
Citation	Filippatos TD, Filippas-Ntekouan S, Pappa E, Panagiotopoulou T, Tsimihodimos V, Elisaf MS. PCSK9 and carbohydrate metabolism: A double-edged sword. World J Diabetes 2017; 8(7): 311-316
URL	http://www.wjgnet.com/1948-9358/full/v8/i7/311.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i7.311

Full Article (PDF)	WJD-8-311.pdf
Full Article (Word)	WJD-8-311.doc
Manuscript File	32099-Review.docx
Answering Reviewers	32099-Answering reviewers.pdf
Audio Core Tip	32099-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32099-Conflict-of-interest statement.pdf
Copyright License Agreement	32099-Copyright assignment.pdf
Peer-review Report	32099-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	32099-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	32099-Scientific misconduct check.pdf
Scientific Editor Work List	32099-Scientific editor work list.pdf