Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	3210
Country	Italy

Received	2013-04-14 17:44
Peer-Review Started	2013-04-15 10:34
To Make the First Decision	2013-05-02 09:04
Return for Revision	2013-05-06 12:03
Revised	2013-05-17 03:45
Second Decision	2013-07-18 15:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 04:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-05 10:04
Publish the Manuscript Online	2013-08-09 16:10

ISSN	2150-5330 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Altered molecular pattern of mucosal healing in Crohn’s disease fibrotic stenosis
Manuscript Source	Invited Manuscript
All Author List	Enzo Ierardi, Floriana Giorgio, Domenico Piscitelli, Mariabeatrice Principi, Santina Cantatore, Maria Grazia Fiore, Roberta Rossi, Michele Barone, Alfredo Di Leo and Carmine Panella
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Gsatroenterology, Department of Medical and Surgical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 71100 Foggia, Italy. enzo.ierardi@fastwenet.it
Key Words	Crohn’s disease; Fibrotic stenosis; Tumor necrosis factor-; Syndecan 1; Basic fibroblast growth factor
Core Tip	The present manuscript reports a study of molecular pattern in the course of stenotic complication of Crohn’s disease. We have studied the interaction among the main cytokine [tumor necrosis factor-? (TNF-?)], an adhesion molecule (syndecan 1) and a growth factor basic fibroblast growth factor which are strictly involved in damage repair and mucosal healing, as showed in a previous study. In this study we demonstrated that a deep dysregulation of interaction of these three factors may support stenotic fibrosis in Crohn’s disease and suggest that this condition needs to be investigated before a biological treatment since TNF-? lack downregulation could further stimulate fibrogenesis.
Publish Date	2013-08-09 16:10
Citation	Ierardi E, Giorgio F, Piscitelli D, Principi M, Cantatore S, Fiore MG, Rossi R, Barone M, Di Leo A, Panella C. Altered molecular pattern of mucosal healing in Crohn’s disease fibrotic stenosis. World J Gastrointest Pathophysiol 2013; 4(3): 53-58
URL	http://www.wjgnet.com/2150-5330/full/v4/i3/53.htm
DOI	http://dx.doi.org/10.4291/wjgp.v4.i3.53

Full Article (PDF)	WJGP-4-53.pdf
Manuscript File	3210-Review.doc
Answering Reviewers	3210-Answering reviewers.pdf
Copyright License Agreement	3210-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3210-Language certificate.pdf
Peer-review Report	3210-Peer review(s).pdf
Scientific Editor Work List	3210-Scientific editor work list.doc