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Articles Published Processes
5/20/2017 12:26:24 PM | Browse: 1270 | Download: 2352
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Received |
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2016-12-28 10:12 |
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Peer-Review Started |
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2016-12-28 21:24 |
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To Make the First Decision |
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2017-02-10 08:44 |
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Return for Revision |
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2017-02-13 13:14 |
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Revised |
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2017-03-11 16:01 |
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Second Decision |
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2017-04-14 17:31 |
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Accepted by Journal Editor-in-Chief |
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2017-04-14 18:09 |
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Accepted by Executive Editor-in-Chief |
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2017-04-21 15:16 |
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Articles in Press |
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2017-04-21 15:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-09 10:29 |
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Publish the Manuscript Online |
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2017-05-20 12:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wael M Abdel-Rahman, Noura A Al-khayyal, Vidhya A Nair, S R Aravind and Maha Saber-Ayad |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Terry Fox Foundation for Cancer Research |
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| Corresponding Author |
Wael M Abdel-Rahman, MD, PhD, Associate Professor, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, University City Road, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae |
| Key Words |
AXL; Breast cancer; Chemotherapy; Colon cancer; Invasion |
| Core Tip |
AXL receptor tyrosine kinase (AXL) is emerging as an attractive molecular target in cancer therapy. We showed that it is regulated by TP53 in colon and breast cancer cells, and it contributes to epithelial to mesenchymal transition and response to therapy in these tumors. We also showed that it could be linked to other carcinogenic pathways, such as the Wnt/β-catenin signaling pathway in colorectal cancer. These interactions should be considered carefully when designing AXL based therapy, because AXL could trigger the emergence of aggressive clones after inappropriate therapy. |
| Publish Date |
2017-05-20 12:26 |
| Citation |
Abdel-Rahman WM, Al-khayyal NA, Nair VA, Aravind SR, Saber-Ayad M. Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations. World J Gastroenterol 2017; 23(19): 3440-3448 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i19/3440.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i19.3440 |
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