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Articles Published Processes
4/20/2017 3:58:56 PM | Browse: 1080 | Download: 2135
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Received |
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2016-12-29 10:03 |
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Peer-Review Started |
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2016-12-30 17:06 |
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To Make the First Decision |
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2017-01-19 10:37 |
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Return for Revision |
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2017-01-23 08:24 |
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Revised |
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2017-02-13 01:53 |
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Second Decision |
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2017-03-09 13:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-15 09:55 |
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Articles in Press |
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2017-03-15 09:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-13 15:23 |
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Publish the Manuscript Online |
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2017-04-20 15:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Agata Bartczak, Jianhua Zhang, Oyedele Adeyi, Achiya Amir, David Grant, Reginald Gorczynski, Nazia Selzner, Andrzej Chruscinski and Gary A Levy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Heart and Stroke Foundation of Canada |
G-13-0002851 |
| the Canadian Institutes of Health Research Training Program in Regenerative Medicine |
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| Ontario Graduate Scholarship in Science and Technology |
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| Corresponding Author |
Dr. Gary A Levy, Professor, Multi Organ Transplant Program, University Health Network, 585 University Avenue, PMB 11-182, Toronto, Ontario M5G 2N2, Canada. gary.levy@uhn.ca |
| Key Words |
Fibrinogen-like protein 2; Colitis; Regulatory T cells; Transgenic mouse; Inflammatory bowel disease |
| Core Tip |
This study investigates the effect of overexpression of fibrinogen-like protein 2 (FGL2) on T cell-induced colitis in mice. For these experiments, effector T cells (Teff) and regulatory T cells (Treg) were isolated from a newly generated line of transgenic mice that ubiquitously overexpress FGL2 (fgl2Tg). Following injection in Rag1-/- mice, fgl2Tg Treg were present in high numbers in mesenteric lymph nodes and were superior to fgl2+/+ Treg in preventing T cell-induced colitis. Fgl2Tg Teff were not capable of inducing colitis. This work is important in showing that the immunoregulatory molecule FGL2 may be useful in the treatment of colitis. |
| Publish Date |
2017-04-20 15:58 |
| Citation |
Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA. Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis. World J Gastroenterol 2017; 23(15): 2673-2684 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i15/2673.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i15.2673 |
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