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Articles Published Processes
4/28/2017 10:26:16 AM | Browse: 1613 | Download: 2481
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Received |
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2016-12-29 09:11 |
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Peer-Review Started |
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2016-12-30 09:51 |
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To Make the First Decision |
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2017-02-23 09:32 |
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Return for Revision |
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2017-02-28 12:59 |
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Revised |
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2017-03-14 10:08 |
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Second Decision |
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2017-03-28 16:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-31 08:01 |
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Articles in Press |
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2017-03-31 08:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-20 09:59 |
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Publish the Manuscript Online |
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2017-04-28 10:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Markus Brückner, Jan Heidemann, Tobias M Nowacki, Friederike Cordes, Jörg Stypmann, Philipp Lenz, Faekah Gohar, Andreas Lügering and Dominik Bettenworth |
| Funding Agency and Grant Number |
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| Corresponding Author |
Markus Brückner, MD, Department of Medicine B, University Hospital of Münster, Albert-Schweitzer-Campus 1, D-48149 Münster,
Germany. markus.brueckner@ukmuenster.de |
| Key Words |
Colitis; Dextran sodium-sulfate; AOM-DSS; Carcinogenesis; Ultrasound; Contrast-enhanced ultrasound; Vascular endothelial growth factor; Mucosal addressin cellular adhesion molecule-1 |
| Core Tip |
Murine models of colitis and carcinogenesis are widely used to study novel diagnostic approaches and to preclinically evaluate promising drug candidates. However, valid assessment of severity of inflammation or cancer development routinely requires post mortem histological analysis. Our study provides evidence that non-invasive contrast enhanced ultrasound (CEUS) is feasible to specifically target intestinal inflammation and carcinogenesis. While MAdCAM-1-directed CEUS follows the severity of murine dextran sodium-sulfate (DSS)-colitis, the use of VEGF- targeted contrast agent allows for characterization of cancer development in the AOM/DSS-induced model of colitis-associated cancer. |
| Publish Date |
2017-04-28 10:26 |
| Citation |
Brückner M, Heidemann J, Nowacki TM, Cordes F, Stypmann J, Lenz P, Gohar F, Lügering A, Bettenworth D. Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound. World J Gastroenterol 2017; 23(16): 2899-2911 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i16/2899.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i16.2899 |
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