Publication Name	World Journal of Gastroenterology
Manuscript ID	32263
Country	Italy

Received	2016-12-29 09:06
Peer-Review Started	2016-12-30 11:12
First Decision by Editorial Office Director
Return for Revision	2017-03-17 14:59
Revised	2017-03-31 04:22
Publication Fee Transferred
Second Decision by Editor	2017-06-16 12:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-06-19 08:39
Articles in Press	2017-06-19 08:39
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-26 01:36
Publish the Manuscript Online	2017-07-07 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Marco Fiore, Alberto Enrico Maraolo, Ivan Gentile, Guglielmo Borgia, Sebastiano Leone, Pasquale Sansone, Maria Beatrice Passavanti, Caterina Aurilio and Maria Caterina Pace
Funding Agency and Grant Number
Corresponding Author	Marco Fiore, MD, Department of Anesthesiological, Surgical and Emergency Sciences, University of Campania “Luigi Vanvitelli”, Piazza Miraglia 2, 80138 Naples, Italy. marco.fiore@hotmail.it
Key Words	Hospital-acquired infections; Nosocomial spontaneous bacterial peritonitis; Multidrug resistant bacteria; Cirrhosis; Critically ill patient
Core Tip	Nosocomial spontaneous bacterial peritonitis (N-SBP) develops in up to one-third of cirrhotic patients. The overall 30-d survival for N-SBP is only 20%, also due to an inadequate empirical antibiotic therapy (EAT). The aim of our Sistematic Review is to describe N-SBP bacterial aetiology and the prevalence of multiple drug resistance (MDR) pathogens to suggest which EAT may be adequate in these entities. After careful evaluation 9 studies were identified. The overall proportion of MDR bacteria was up to 22%-73% of cases. EAT with a carbapenem plus daptomycin and a Beta-lactam active against methicillin-resistant cocci should be considered in centers with a high prevalence of MDR bacteria.
Publish Date	2017-07-07 11:41
Citation	Fiore M, Maraolo AE, Gentile I, Borgia G, Leone S, Sansone P, Passavanti MB, Aurilio C, Pace MC. Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review. World J Gastroenterol 2017; 23(25): 4654-4660
URL	http://www.wjgnet.com/1007-9327/full/v23/i25/4654.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i25.4654

Full Article (PDF)	WJG-23-4654.pdf
Full Article (Word)	WJG-23-4654.doc
Manuscript File	32263-Review.doc
Answering Reviewers	32263-Answering reviewers.pdf
Audio Core Tip	32263-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32263-Conflict-of-interest statement.pdf
Copyright License Agreement	32263-Copyright assignment.pdf
Peer-review Report	32263-Peer-review(s).pdf
Scientific Editor Work List	32263-Scientific editor work list.pdf
Scientific Editor Work List	32263-Scientific misconduct check.pdf