Publication Name	World Journal of Gastroenterology
Manuscript ID	32310
Country	Japan

Received	2017-01-03 14:53
Peer-Review Started	2017-01-04 10:26
To Make the First Decision	2017-02-09 13:46
Return for Revision	2017-02-20 10:52
Revised	2017-02-28 04:13
Second Decision	2017-03-28 16:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-31 08:02
Articles in Press	2017-03-31 08:02
Publication Fee Transferred	2017-04-12 07:34
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-05 14:38
Publish the Manuscript Online	2017-05-15 06:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B
Manuscript Source	Unsolicited Manuscript
All Author List	Xuyang Wang, Naoki Oishi, Tetsuro Shimakami, Taro Yamashita, Masao Honda, Seishi Murakami and Shuichi Kaneko
Funding Agency and Grant Number
Corresponding Author	Naoki Oishi, MD, PhD, Researcher, Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Ishikawa, Japan. ooishi@m-kanazawa.jp
Key Words	Hepatitis B virus X protein; Hepatocellular carcinoma; KDM5B; Progenitor cell; Tumorigenesis
Core Tip	The role of epigenetic regulation in cancer biology has been the subject of several studies. These chromatin structure modifiers have been increasingly shown to facilitate several steps of cancer progression. However, the epigenetic regulation of hepatocellular carcinoma has not been elucidated. We assumed that multifunctional protein hepatitis B virus X (HBx) protein, may affect epigenetic regulation of Hepatocellular carcinoma. We showed that HBx activated the histone demethylase KDM5B and induced HPC-like features in hepatocellular carcinoma (HCC) in this study. Our results suggested that histone demethylases may be an important therapeutic target against HBV-related HCC cases.
Publish Date	2017-05-15 06:16
Citation	Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S. Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. World J Gastroenterol 2017; 23(18): 3252-3261
URL	http://www.wjgnet.com/1007-9327/full/v23/i18/3252.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i18.3252

Full Article (PDF)	WJG-23-3252.pdf
Full Article (Word)	WJG-23-3252.doc
Manuscript File	32310-Review.docx
Answering Reviewers	32310-Answering reviewers.pdf
Audio Core Tip	32310-Audio core tip.mp3
Biostatistics Review Certificate	32310-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32310-Conflict-of-interest statement.pdf
Copyright License Agreement	32310-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	32310-Language certificate.pdf
Peer-review Report	32310-Peer-review(s).pdf
Scientific Misconduct Check	32310-Scientific misconduct check.pdf
Scientific Editor Work List	32310-Scientific editor work list.pdf