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5/15/2017 6:16:31 AM | Browse: 85 | Download: 70
Publication Name World Journal of Gastroenterology
Manuscript ID 32310
Country of Manuscript Source Japan
Received
2017-01-03 14:53
Peer-Review Started
2017-01-04 10:26
To Make the First Decision
2017-02-09 13:46
Return for Revision
2017-02-20 10:52
Revised
2017-02-28 04:13
Second Decision
2017-03-28 16:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-31 08:02
Articles In Press
2017-03-31 08:02
Publication Fee Transferred
2017-04-12 07:34
Edit the Manuscript by Languag Editor
Typeset the Manuscript
2017-05-05 14:38
Publish the Manuscript Online
2017-05-15 06:16
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B
Manuscript Source Unsolicited Manuscript
All Author List Xuyang Wang, Naoki Oishi, Tetsuro Shimakami, Taro Yamashita, Masao Honda, Seishi Murakami and Shuichi Kaneko
Funding Agency and Grant Number
Correspondence To Naoki Oishi, MD, PhD, Researcher, Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Ishikawa, Japan. ooishi@m-kanazawa.jp
Keywords Hepatitis B virus X protein; Hepatocellular carcinoma; KDM5B; Progenitor cell; Tumorigenesis
Core Tip The role of epigenetic regulation in cancer biology has been the subject of several studies. These chromatin structure modifiers have been increasingly shown to facilitate several steps of cancer progression. However, the epigenetic regulation of hepatocellular carcinoma has not been elucidated. We assumed that multifunctional protein hepatitis B virus X (HBx) protein, may affect epigenetic regulation of Hepatocellular carcinoma. We showed that HBx activated the histone demethylase KDM5B and induced HPC-like features in hepatocellular carcinoma (HCC) in this study. Our results suggested that histone demethylases may be an important therapeutic target against HBV-related HCC cases.
Publish Date 2017-05-15 06:16
Citation Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S. Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. World J Gastroenterol 2017; 23(18): 3252-3261
Url http://www.wjgnet.com/1007-9327/full/v23/i18/3252.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i18.3252
Full Article (PDF) WJG-23-3252.pdf
Full Article (Word) WJG-23-3252.doc
Revised Manuscript 32310-Review.docx
Peer-review Report 32310-Peer-review(s).pdf
Answering Reviewers 32310-Answering reviewers.pdf
Scientific Misconduct Check 32310-Scientific misconduct check.pdf
Scientific Editor Work List 32310-Scientific editor work list.pdf
Audio 32310-Audio core tip.mp3
Biostatistics Statement 32310-Biostatistics statement.pdf
Conflict-of-Interest Statement 32310-Conflict-of-interest statement.pdf
Copyright Assignment 32310-Copyright assignment.pdf
Non-Native Speakers of English 32310-Language certificate.pdf
Scientific Research Process 32310-Scientific research process.pdf