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6/20/2017 12:12:53 PM | Browse: 925 | Download: 1936
Publication Name World Journal of Gastroenterology
Manuscript ID 32318
Country/Territory China
Received
2017-01-03 14:39
Peer-Review Started
2017-01-04 10:56
To Make the First Decision
2017-02-09 13:46
Return for Revision
2017-02-16 17:29
Revised
2017-03-14 18:23
Second Decision
2017-03-28 16:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-31 08:03
Articles in Press
2017-03-31 08:03
Publication Fee Transferred
2017-04-05 07:14
Edit the Manuscript by Language Editor
2017-05-15 03:59
Typeset the Manuscript
2017-06-08 12:22
Publish the Manuscript Online
2017-06-20 12:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title miR-382 functions as a tumor suppressor against esophageal squamous cell carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jie Feng, Bo Qi, Ling Guo, Ling-Yun Chen, Xiu-Feng Wei, Yu-Zhen Liu and Bao-Sheng Zhao
Funding Agency and Grant Number
Funding Agency Grant Number
Key Technologies R&D Program of Science and Technology Commission of Henan Province (to Zhao BS) 152102310110
Key Science and Technique Fund of Xinxiang (to Zhao BS) ZG15018
Corresponding Author Bao-Sheng Zhao, MD, Professor of Surgery, Chief, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China. zhaobscn@126.com
Key Words miR-382; Esophageal squamous cell carcinoma; Tumor suppressor; Proliferation; Migration; Invasion
Core Tip Our previous study revealed that miR-382 was significantly down-regulated in esophageal squamous cell carcinoma (ESCC) patients with short-term motility, implying that miR-382 may display antitumor function in ESCC development and metastasis. We present here that miR-382 functions as a tumor suppressor by inhibiting proliferation, migration, invasion and epithelial-mesenchymal transition, in addition to inducing cell cycle arrest, apoptosis and autophagy in Eca109 cells. Inhibitory influence on protein translation mediated by mTOR/4E-BP1 signaling might be involved in the antitumor activity of miR-382 against ESCC. Thus, manipulation of miR-382 level can be a potentially therapeutic intervention for ESCC.
Publish Date 2017-06-20 12:12
Citation Feng J, Qi B, Guo L, Chen LY, Wei XF, Liu YZ, Zhao BS. miR-382 functions as a tumor suppressor against esophageal squamous cell carcinoma. World J Gastroenterol 2017; 23(23): 4243-4251
URL http://www.wjgnet.com/1007-9327/full/v23/i23/4243.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i23.4243
Full Article (PDF) WJG-23-4243.pdf
Full Article (Word) WJG-23-4243.doc
Manuscript File 32318-Review.docx
Answering Reviewers 32318-Answering reviewers.pdf
Audio Core Tip 32318-Audio core tip.mp3
Biostatistics Review Certificate 32318-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32318-Conflict-of-interest statement.pdf
Copyright License Agreement 32318-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32318-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 32318-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32318-Language certificate.pdf
Supplementary Material 32318-Figures.pptx
Peer-review Report 32318-Peer-review(s).pdf
Scientific Misconduct Check 32318-Scientific misconduct check.pdf
Scientific Editor Work List 32318-Scientific editor work list.pdf