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Articles Published Processes
6/20/2017 12:12:53 PM | Browse: 1068 | Download: 2370
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Received |
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2017-01-03 14:39 |
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Peer-Review Started |
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2017-01-04 10:56 |
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To Make the First Decision |
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2017-02-09 13:46 |
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Return for Revision |
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2017-02-16 17:29 |
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Revised |
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2017-03-14 18:23 |
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Second Decision |
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2017-03-28 16:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-31 08:03 |
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Articles in Press |
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2017-03-31 08:03 |
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Publication Fee Transferred |
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2017-04-05 07:14 |
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Edit the Manuscript by Language Editor |
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2017-05-15 03:59 |
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Typeset the Manuscript |
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2017-06-08 12:22 |
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Publish the Manuscript Online |
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2017-06-20 12:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-382 functions as a tumor suppressor against esophageal squamous cell carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Feng, Bo Qi, Ling Guo, Ling-Yun Chen, Xiu-Feng Wei, Yu-Zhen Liu and Bao-Sheng Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Technologies R&D Program of Science and Technology Commission of Henan Province (to Zhao BS) |
152102310110 |
| Key Science and Technique Fund of Xinxiang (to Zhao BS) |
ZG15018 |
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| Corresponding Author |
Bao-Sheng Zhao, MD, Professor of Surgery, Chief, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China. zhaobscn@126.com |
| Key Words |
miR-382; Esophageal squamous cell carcinoma; Tumor suppressor; Proliferation; Migration; Invasion |
| Core Tip |
Our previous study revealed that miR-382 was significantly down-regulated in esophageal squamous cell carcinoma (ESCC) patients with short-term motility, implying that miR-382 may display antitumor function in ESCC development and metastasis. We present here that miR-382 functions as a tumor suppressor by inhibiting proliferation, migration, invasion and epithelial-mesenchymal transition, in addition to inducing cell cycle arrest, apoptosis and autophagy in Eca109 cells. Inhibitory influence on protein translation mediated by mTOR/4E-BP1 signaling might be involved in the antitumor activity of miR-382 against ESCC. Thus, manipulation of miR-382 level can be a potentially therapeutic intervention for ESCC. |
| Publish Date |
2017-06-20 12:12 |
| Citation |
Feng J, Qi B, Guo L, Chen LY, Wei XF, Liu YZ, Zhao BS. miR-382 functions as a tumor suppressor against esophageal squamous cell carcinoma. World J Gastroenterol 2017; 23(23): 4243-4251 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i23/4243.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i23.4243 |
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