Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	32358
Country	United States

Received	2017-01-04 09:14
Peer-Review Started	2017-01-07 16:57
To Make the First Decision	2017-02-17 09:18
Return for Revision	2017-02-17 15:06
Revised	2017-03-04 04:11
Second Decision	2017-03-13 10:49
Accepted by Journal Editor-in-Chief	2017-03-14 00:27
Accepted by Executive Editor-in-Chief	2017-03-24 10:47
Articles in Press	2017-03-24 10:47
Publication Fee Transferred	2017-05-02 19:18
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-06 02:21
Publish the Manuscript Online	2017-06-14 04:11

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression
Manuscript Source	Unsolicited Manuscript
All Author List	Radim Moravec, Rao Divi and Mukesh Verma
Funding Agency and Grant Number	Funding Agency Grant Number Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Rockville MD 22805, United States
Corresponding Author	Mukesh Verma, PhD, Branch Chief, Methods and Technologies Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Rockville, MD 20850, United States. vermam@mail.nih.gov
Key Words	Circulating tumor cells; Digital pathology; Early detection; Exosomes; Pancreatic cancer
Core Tip	Pancreatic cancer (PC) is a leading cause of cancer-related death. PC mutations accumulate 20 years before patient death with metastatic mutations occurring late in the process. Metastatic risk increases dramatically when tumor diameter is greater than 1 cm. Most PC cases are diagnosed at late metastatic stages when survival is short. Outcomes could be improved if non-invasive methods could detect early stages of the disease and guide treatment decisions. Recent studies indicate this may be possible with application of digital pathology imaging, screening of CA 19-9 with additional markers, and detecting circulating tumor material in early-stage PC patients.
Publish Date	2017-06-14 04:11
Citation	CITATION Moravec R, Divi R, Verma M. Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression. World J Gastrointest Oncol 2017; 9(6): 235-250
URL	http://www.wjgnet.com/1948-5204/full/v9/i6/235.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i6.235

Full Article (PDF)	WJGO-9-235.pdf
Full Article (Word)	WJGO-9-235.doc
Manuscript File	32358-Review.docx
Answering Reviewers	32358-Answering reviewers.pdf
Audio Core Tip	32358-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32358-Conflict-of-interest statement.pdf
Copyright License Agreement	32358-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32358-Grant application form(s).pdf
Peer-review Report	32358-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	32358-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	32358-Scientific misconduct check.pdf
Scientific Editor Work List	32358-Scientific editor work list.pdf